# 骨の再生医療：骨再生を可能にするセラミック系骨補填材の開発

https://mdr.nims.go.jp/datasets/746f8287-cc86-4f54-b2d1-c8a64a278791

## File

- [2024_骨の再生医療_杉浦.pdf](https://mdr.nims.go.jp/filesets/68dbb6df-adef-437b-b578-1daf0debdda7/download) ([Detail](https://mdr.nims.go.jp/filesets/68dbb6df-adef-437b-b578-1daf0debdda7.md))

## Id

746f8287-cc86-4f54-b2d1-c8a64a278791

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-22T04:41:29.765443Z

## Updated at

2024-11-22T07:30:44.903023Z

## Published at

2024-11-22T07:30:45.053646Z

## Doi



## First published url

https://doi.org/10.2465/gkk.231209

## Date published

2024-05-13

## Recorded date published

2024

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: 骨の再生医療：骨再生を可能にするセラミック系骨補填材の開発
  title_type: original
  lang: ja

## Description

- description: In orthopedics and oral surgery, clinical trials are being conducted
    to examine the reconstruction and regeneration of bone defects caused by injuries
    and diseases. Bone substitutes, mainly composed of calcium phosphate, are employed
    as biomaterials to reconstruct and regenerate bone defects that cannot be covered
    by autogenous bone grafts. However, the bone regeneration abilities of existing
    bone grafting materials are insufficient. Most candidates for bone grafting materials
    are elderly patients older than 60 years, so improving the bone regeneration capacity
    of bone grafting materials is a major clinical problem. We have been investigating
    the enhancement of bone substitutes via ionic insertion, an original method of
    controlling calcium phosphate crystals and adding elements. In this review, we
    describe our studies on the addition of silica, a bone–active factor, to calcium
    phosphate and the usefulness of silica–loaded calcium phosphate as a bone replacement
    material based on the ionic insertion method. The bone regeneration ability of
    silica–loaded calcium phosphate was several times higher than that of the current
    carbonate apatite bone material. Silica–loaded calcium phosphate is expected to
    be applicable to clinical cases that were difficult to apply in the past; it will
    also significantly help improve the quality of life of patients, especially the
    elderly.
  description_type: abstract
  lang: und

## Creator

- name: 杉浦 悠紀
  role: author
- name: 小野 文子
  role: author
- name: 野原 正勝
  role: author
- name: 新津 甲大
  role: author
  orcid: https://orcid.org/0000-0002-0430-8868
  organization: National Institute for Materials Science
- name: 齋藤 靖子
  role: author

## Contact agent



## Publisher

organization: 一般社団法人　日本鉱物科学会

## Managing organization



## Keyword

- subject: 再生医療
  schema: not_defined
- subject: 骨再生
  schema: not_defined
- subject: 骨補填材
  schema: not_defined

## Rights

- identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: 岩石鉱物科学
  issn: '13497979'
  volume: '53'
  issue: '1'
  article_number: '231209'

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



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## Fileset

- id: 68dbb6df-adef-437b-b578-1daf0debdda7
  filename: 2024_骨の再生医療_杉浦.pdf
  content_type: application/pdf
  size: 9027171
  md5: c60eb8464695156c65d6fd2f29e14ac0

## Thumbnail

fileset_id: 68dbb6df-adef-437b-b578-1daf0debdda7
filename: 2024_骨の再生医療_杉浦.pdf