Download file (8.61MB)
Download as zip (8.51MB)

コレクション

引用

説明:

In orthopedics and oral surgery, clinical trials are being conducted to examine the reconstruction and regeneration of bone defects caused by injuries and diseases. Bone substitutes, mainly composed of calcium phosphate, are employed as biomaterials to reconstruct and regenerate bone defects that cannot be covered by autogenous bone grafts. However, the bone regeneration abilities of existing bone grafting materials are insufficient. Most candidates for bone grafting materials are elderly patients older than 60 years, so improving the bone regeneration capacity of bone grafting materials is a major clinical problem. We have been investigating the enhancement of bone substitutes via ionic insertion, an original method of controlling calcium phosphate crystals and adding elements. In this review, we describe our studies on the addition of silica, a bone–active factor, to calcium phosphate and the usefulness of silica–loaded calcium phosphate as a bone replacement material based on the ionic insertion method. The bone regeneration ability of silica–loaded calcium phosphate was several times higher than that of the current carbonate apatite bone material. Silica–loaded calcium phosphate is expected to be applicable to clinical cases that were difficult to apply in the past; it will also significantly help improve the quality of life of patients, especially the elderly.

権利情報:

• In Copyright
  

キーワード: 再生医療, 骨再生, 骨補填材

刊行年月日: 2024-05-13

出版者: 一般社団法人　日本鉱物科学会

掲載誌:

• 岩石鉱物科学 (ISSN: 13497979) vol. 53 issue. 1 231209

研究助成金:

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.2465/gkk.231209

関連資料:

その他の識別子:

連絡先:

更新時刻: 2024-11-22 16:30:44 +0900

MDRでの公開時刻: 2024-11-22 16:30:45 +0900