# Diffusion of DNA on Atomically Flat 2D Material Surfaces

https://mdr.nims.go.jp/datasets/74314075-c4c0-47d1-aeb8-8b313bd7a2b3

## File

- [shin-et-al-2025-diffusion-of-dna-on-atomically-flat-2d-material-surfaces.pdf](https://mdr.nims.go.jp/filesets/4c198194-d906-4f68-b6e3-a94af0bffb81/download) ([Detail](https://mdr.nims.go.jp/filesets/4c198194-d906-4f68-b6e3-a94af0bffb81.md))

## Id

74314075-c4c0-47d1-aeb8-8b313bd7a2b3

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-02-14T11:44:09.932117Z

## Updated at

2026-02-16T23:30:14.030416Z

## Published at

2026-02-16T09:00:51.166495Z

## Doi



## First published url

https://doi.org/10.1021/acsnano.4c16277

## Date published

2025-06-17

## Recorded date published

2025-6-17

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Diffusion of DNA on Atomically Flat 2D Material Surfaces
  title_type: original
  lang: en

## Description

- description: Accurate localization and delivery of biomolecules is pivotal for building
    tools to understand biology. The interactions of biomolecules with atomically
    flat 2D surfaces offer a means to realize both the localization and delivery,
    yet experimental utilization of such interactions has remained elusive. By combining
    single-molecule detection methods with computational approaches, we have comprehensively
    characterized the interactions of individual DNA molecules with hexagonal boron
    nitride (hBN) surfaces. Our experiments directly show that, upon binding to a
    hBN surface, a DNA molecule retains its ability to diffuse along the surface.
    Further, we show that the magnitude and direction of such diffusion can be controlled
    by the DNA length, the surface topography, and atomic defects. By fabricating
    a narrow hBN ribbon structure, we achieved pseudo-1D confinement, demonstrating
    its potential for nanofluidic guiding of biomolecules. Our work sets the stage
    for engineering 2D materials for high-throughput manipulation of single biomolecules
    and their applications in nanobiotechnology.
  description_type: abstract
  lang: und

## Creator

- name: Dong Hoon Shin
  role: author
- name: Sung Hyun Kim
  role: author
- name: Kush Coshic
  role: author
- name: Kenji Watanabe
  role: author
  orcid: https://orcid.org/0000-0003-3701-8119
  organization: National Institute for Materials Science
- name: Takashi Taniguchi
  role: author
  orcid: https://orcid.org/0000-0002-1467-3105
  organization: National Institute for Materials Science
- name: Gerard J. Verbiest
  role: author
- name: Sabina Caneva
  role: author
- name: Aleksei Aksimentiev
  role: author
- name: Peter G. Steeneken
  role: author
- name: Chirlmin Joo
  role: author

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

## Managing organization



## Keyword

- subject: 'DNA diffusion
    '
  schema: not_defined
- subject: 2D material surfaces
  schema: not_defined
- subject: 'hexagonal boron nitride (hBN)
    '
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/
  date_licensed: 2025-06-05

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: ACS Nano
  issn: '19360851'
  volume: '19'
  issue: '23'
  start_page: 21307
  end_page: 21318

## Conference



## Related item



## Funding

- funder_name: Technische Universiteit Delft
- identifier: NRF-2023R1A2C2004745
  funder_name: Ministry of Science and ICT, South Korea
- identifier: RS-2023-00261876
  funder_name: Ministry of Science and ICT, South Korea
- identifier: '881603'
  funder_name: H2020 Future and Emerging Technologies
- identifier: RGP00026/2019
  funder_name: Human Frontier Science Program
- identifier: RGP0047/2020
  funder_name: Human Frontier Science Program
- identifier: '101041486'
  funder_name: H2020 European Research Council
- identifier: Frontier 10-10
  funder_name: Ewha Womans University
- identifier: DMR-1827346
  funder_name: Division of Materials Research
- funder_name: Korea University
- identifier: VI.C.202.015
  funder_name: Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- funder_name: Kavli Institute of Nanoscience Delft

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Custom property



## Fileset

- id: 4c198194-d906-4f68-b6e3-a94af0bffb81
  filename: shin-et-al-2025-diffusion-of-dna-on-atomically-flat-2d-material-surfaces.pdf
  content_type: application/pdf
  size: 10397475
  md5: 0612b9bbe13f1c5faff343da6f35fc69

## Thumbnail

fileset_id: 4c198194-d906-4f68-b6e3-a94af0bffb81
filename: shin-et-al-2025-diffusion-of-dna-on-atomically-flat-2d-material-surfaces.pdf