# Robust aortic media adhesion using hydrophobically modified Alaska pollock gelatin-based adhesive for aortic dissections

https://mdr.nims.go.jp/datasets/6f48442f-7d89-44a1-8225-eaa0092a427b

## File

- [Manuscript_ItoTemmei_R1 after approved.docx](https://mdr.nims.go.jp/filesets/f20f8875-8047-4cc6-bc97-bb7f290031bd/download) ([Detail](https://mdr.nims.go.jp/filesets/f20f8875-8047-4cc6-bc97-bb7f290031bd.md))
- [Supporting Infomation.docx](https://mdr.nims.go.jp/filesets/d02d9fb2-899f-4ad7-a3ec-bbf4a85aa4d1/download) ([Detail](https://mdr.nims.go.jp/filesets/d02d9fb2-899f-4ad7-a3ec-bbf4a85aa4d1.md))

## Id

6f48442f-7d89-44a1-8225-eaa0092a427b

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-01-10T01:03:02.136540Z

## Updated at

2025-01-05T07:30:43.825602Z

## Published at

2025-01-05T07:30:43.913560Z

## Doi

https://doi.org/10.48505/nims.4350

## First published url

https://doi.org/10.1002/jbm.b.35361

## Date published

2024-01-05

## Recorded date published

2024-1

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Robust aortic media adhesion using hydrophobically modified Alaska pollock
    gelatin-based adhesive for aortic dissections
  title_type: original
  lang: en

## Description

- description: Type-A aortic dissection is an acute injury involving the delamination
    of the aorta at the parts of the aortic media. Aldehyde crosslinker-containing
    glues have been used to adhere the media of the dissected aorta before joining
    an artificial graft. These glues effectively adhere to the aortic media; however,
    they show low biocompatibility due to the release of aldehyde compounds. In this
    study, we report innovative adhesives based on hydrophobically-modified Alaska
    pollock gelatin (hm-ApGltn) with different alkyl or cholesteryl groups that adhere
    to the media of the dissected aorta by combining hm-ApGltns with a biocompatible
    crosslinker, pentaerythritol poly(ethylene glycol) ether tetrasuccinimidyl glutarate
    (4S-PEG). The modification of alkyl or cholesteryl (Chol) groups contributed to
    enhanced adhesion strength between porcine aortic media. The adhesion strength
    increased with increasing modification ratios of alkyl groups from propanoyl to
    dodecanoyl groups and then decreased at a modification ratio of ~20 mol%. Porcine
    aortic media adhered using 7.5Chol-ApGltn adhesive showed stretchability even
    when expanded and shrunk vertically by 25% at least five times. Hm-ApGltn adhesives
    subcutaneously injected into the backs of mice showed no severe inflammation and
    were degraded during the implantation period. These results indicated that hm-ApGltn
    adhesives have potential applications in type-A aortic dissection.
  description_type: abstract
  lang: eng

## Creator

- name: Temmei Ito
  role: author
  organization: National Institute for Materials Science
- name: Ryo Mizuta
  role: author
  organization: National Institute for Materials Science
- name: Shima Ito
  role: author
  organization: National Institute for Materials Science
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: Alaska pollock gelatin
  schema: not_defined
- subject: cardiovascular
  schema: not_defined
- subject: hydrogel
  schema: not_defined
- subject: tissue adhesion
  schema: not_defined

## Rights

- description: 'This is the peer reviewed version of the following article: Robust
    aortic media adhesion using hydrophobically modified Alaska pollock gelatin-based
    adhesive for aortic dissections, which has been published in final form at https://doi.org/10.1002/jbm.b.35361.
    This article may be used for non-commercial purposes in accordance with Wiley
    Terms and Conditions for Use of Self-Archived Versions. This article may not be
    enhanced, enriched or otherwise transformed into a derivative work, without express
    permission from Wiley or by statutory rights under applicable legislation. Copyright
    notices must not be removed, obscured or modified. The article must be linked
    to Wiley’s version of record on Wiley Online Library and any embedding, framing
    or otherwise making available the article or pages thereof by third parties from
    platforms, services and websites other than Wiley Online Library must be prohibited.'
  identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2024-01-05
end_date: 2025-01-05

## Journal

- title: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS
  issn: '15524973'
  volume: '112'
  issue: '1'
  article_number: e35361

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: f20f8875-8047-4cc6-bc97-bb7f290031bd
  filename: Manuscript_ItoTemmei_R1 after approved.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 6675906
  md5: 6616270166762ec41e106b4703b564df
- id: d02d9fb2-899f-4ad7-a3ec-bbf4a85aa4d1
  filename: Supporting Infomation.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 815175
  md5: 9637bd7eb70b2f42ab7bc210f3cc5d01

## Thumbnail

fileset_id: f20f8875-8047-4cc6-bc97-bb7f290031bd
filename: Manuscript_ItoTemmei_R1 after approved.docx