# Quantitative Evaluation of Nucleic Acid Degradability of Copper Alloy Surfaces and Its Correlation to Antibacterial Activity

https://mdr.nims.go.jp/datasets/6bfd892c-72e0-4618-9f92-eafce99f2b03

## File

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## Id

6bfd892c-72e0-4618-9f92-eafce99f2b03

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-01-24T08:07:17.269807Z

## Updated at

2024-01-25T00:56:33.043021Z

## Published at

2024-01-25T03:30:18.443828Z

## Doi



## First published url

https://doi.org/10.3390/antibiotics10121439

## Date published

2021-11-24

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Quantitative Evaluation of Nucleic Acid Degradability of Copper Alloy Surfaces
    and Its Correlation to Antibacterial Activity
  title_type: original
  lang: en

## Description

- description: Copper (Cu) and its alloys have bactericidal activity known as “contact
    killing” with degradation of nucleic acids inside the bacteria, which is beneficial
    to inhibit horizontal gene transfer (HGF). In order to understand the nucleic
    acid degradability of Cu and its alloy surfaces, we developed a new in vitro method
    to quantitatively evaluate it by a swab method under a “dry” condition and compared
    it with that of commercially available antibacterial materials such as antibacterial
    stainless steel, pure silver, and antibacterial resins. As a result, only Cu and
    its alloys showed continuous degradation of nucleic acids for up to 6 h of contact
    time. The nucleic acid degradability levels of the Cu alloys and other antibacterial
    materials correlate to their antibacterial activities evaluated by a film method
    referring to JIS Z 2801:2012 for Gram-negative (Escherichia coli) and Gram-positive
    (Staphylococcus aureus) bacteria. Nucleic acid degradation by copper (I) and (II)
    chlorides was confirmed at the ranges over 10 mM and 1–20 mM, respectively, suggesting
    that the copper ion release may be responsible for the degradation of the nucleic
    acids on Cu and its alloy surfaces. In conclusion, the higher Cu content in the
    alloys gave higher nucleic acid degradability and higher antibacterial activities.
  description_type: abstract
  lang: eng

## Creator

- name: Akiko Yamamoto
  role: author
  orcid: https://orcid.org/0000-0002-9182-4886
  organization: National Institute for Materials Science
- name: Shinji Tanaka
  role: author
- name: Keiichiro Ohishi
  role: author

## Contact agent



## Publisher

organization: MDPI AG

## Managing organization



## Keyword

- subject: antimicrobial activities
  schema: not_defined
- subject: antibacterial test
  schema: not_defined
- subject: copper and copper alloys
  schema: not_defined
- subject: DNA degradability
  schema: not_defined
- subject: a swab method
  schema: not_defined

## Rights

- description: "This article is an open access article distributed under the terms
    and\r\nconditions of the Creative Commons Attribution (CC BY) license (https://\r\ncreativecommons.org/licenses/by/4.0/)."
  identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: Antibiotics-Basel
  issn: '20796382'
  volume: '10'
  issue: '12'
  start_page: 1439
  end_page: 1439

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



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## Fileset

- id: 603efdb1-22a2-4468-a334-fbb45fe003f7
  filename: antibiotics-10-01439-v2.pdf
  content_type: application/pdf
  size: 2181204
  md5: 8b883e761dcf6f44b9d4f82405766cfe
- id: fcef55b2-34cd-4507-8635-e61e87b0bf06
  filename: antibiotics-1457295-supplementary.pdf
  content_type: application/pdf
  size: 161656
  md5: 9ece48f0a711051727e79f68173a17fe

## Thumbnail

fileset_id: 603efdb1-22a2-4468-a334-fbb45fe003f7
filename: antibiotics-10-01439-v2.pdf