# Efficacy of Nanofiber Sheets Incorporating Oxaliplatin in Gastrointestinal Cancer Xenograft Models

https://mdr.nims.go.jp/datasets/697697c8-9732-4cb2-a6b1-1e872cd48c42

## File

- [25_Nanomaterials2.pdf](https://mdr.nims.go.jp/filesets/3ab963c3-c4d5-48e1-8ddc-4f921cad44dc/download) ([Detail](https://mdr.nims.go.jp/filesets/3ab963c3-c4d5-48e1-8ddc-4f921cad44dc.md))

## Id

697697c8-9732-4cb2-a6b1-1e872cd48c42

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-12-16T00:25:05.399027Z

## Updated at

2025-12-16T00:55:11.637865Z

## Published at

2025-12-19T05:11:44.778863Z

## Doi



## First published url

https://doi.org/10.3390/nano15191524

## Date published

2025-10-05

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Efficacy of Nanofiber Sheets Incorporating Oxaliplatin in Gastrointestinal
    Cancer Xenograft Models
  title_type: original
  lang: en

## Description

- description: Oxaliplatin is an anticancer drug used to treat colorectal and gastric
    cancers. In many cases, chemotherapy is discontinued due to adverse events caused
    by anticancer drugs. To address this challenge, we developed a sustained-release
    drug delivery system using polycaprolactone sheets embedded with oxaliplatin (oxaliplatin
    sheets) and evaluated their therapeutic potential in murine models of colon and
    gastric cancers. Antitumor efficacy was compared with conventional intraperitoneal
    administration by monitoring tumor volume, body weight, and systemic oxaliplatin
    concentrations over 21 days, along with histopathological assessment of tumors
    and hepatic tissue. Oxaliplatin sheets demonstrated superior tumor suppression,
    significantly reduced Ki-67 positivity, and mitotic indices. Additionally, antitumor
    effects and blood oxaliplatin levels were consistent regardless of implantation
    site. Notably, oxaliplatin sheets significantly decreased weight loss compared
    with intraperitoneal administration. In our analysis of liver pathology, we found
    that hepatic sinusoidal obstruction and hepatocellular degeneration were significantly
    increased after intraperitoneal administration compared with untreated mice and
    mice treated with oxaliplatin sheets. Furthermore, treatment with oxaliplatin
    sheets improved survival. Thus, our oxaliplatin sheets exhibited effective tumor
    control and reduced side effects, indicating their potential as a promising treatment
    for advanced gastric and colorectal cancers.
  description_type: abstract
  lang: und

## Creator

- name: Fusao Sumiyama
  role: author
- name: Hoang Hai Duong
  role: author
- name: Hideyuki Matsushima
  role: author
- name: Kosuke Matsui
  role: author
- name: Terufumi Yoshida
  role: author
- name: Hidekazu Yamamoto
  role: author
- name: Hisashi Kosaka
  role: author
- name: Mitsugu Sekimoto
  role: author
- name: Van Khanh Nguyen
  role: author
- name: Thanh Tung Lai
  role: author
- name: Takuya Ohigashi
  role: author
- name: Tomoya O. Akama
  role: author
- name: Kengo Yoshii
  role: author
- name: Emiho Oe
  role: author
  organization: National Institute for Materials Science
- name: Nanami Fujisawa
  role: author
  orcid: https://orcid.org/0000-0002-8894-1790
  organization: National Institute for Materials Science
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science
- name: Masaki Kaibori
  role: author

## Contact agent



## Publisher

organization: MDPI AG

## Managing organization



## Keyword

- subject: nanofibers
  schema: not_defined
- subject: oxaliplatin
  schema: not_defined
- subject: gastrointestinal cancer
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/
  date_licensed: 2025-10-05

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Nanomaterials
  issn: '20794991'
  volume: '15'
  issue: '19'
  article_number: '1524'

## Conference



## Related item



## Funding

- identifier: 21K08762
  funder_name: Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for
    Scientific Research
- identifier: 20H05877
  funder_name: Grant-in-Aid for Transformative Research Areas
- funder_name: Kansai Medical University

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## Fileset

- id: 3ab963c3-c4d5-48e1-8ddc-4f921cad44dc
  filename: 25_Nanomaterials2.pdf
  content_type: application/pdf
  size: 5480899
  md5: 83866144e6eb018152e6d64fda25591b

## Thumbnail

fileset_id: 3ab963c3-c4d5-48e1-8ddc-4f921cad44dc
filename: 25_Nanomaterials2.pdf