論文 Efficacy of Nanofiber Sheets Incorporating Oxaliplatin in Gastrointestinal Cancer Xenograft Models

Fusao Sumiyama ; Hoang Hai Duong ; Hideyuki Matsushima ; Kosuke Matsui ; Terufumi Yoshida ; Hidekazu Yamamoto ; Hisashi Kosaka ; Mitsugu Sekimoto ; Van Khanh Nguyen ; Thanh Tung Lai ; Takuya Ohigashi ; Tomoya O. Akama ; Kengo Yoshii ; Emiho Oe (National Institute for Materials Science) ; Nanami Fujisawa SAMURAI ORCID (National Institute for Materials Science) ; Mitsuhiro Ebara SAMURAI ORCID (National Institute for Materials Science) ; Masaki Kaibori

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Fusao Sumiyama, Hoang Hai Duong, Hideyuki Matsushima, Kosuke Matsui, Terufumi Yoshida, Hidekazu Yamamoto, Hisashi Kosaka, Mitsugu Sekimoto, Van Khanh Nguyen, Thanh Tung Lai, Takuya Ohigashi, Tomoya O. Akama, Kengo Yoshii, Emiho Oe, Nanami Fujisawa, Mitsuhiro Ebara, Masaki Kaibori. Efficacy of Nanofiber Sheets Incorporating Oxaliplatin in Gastrointestinal Cancer Xenograft Models. Nanomaterials. 2025, 15 (19), 1524. https://doi.org/10.3390/nano15191524

説明:

(abstract)

Oxaliplatin is an anticancer drug used to treat colorectal and gastric cancers. In many cases, chemotherapy is discontinued due to adverse events caused by anticancer drugs. To address this challenge, we developed a sustained-release drug delivery system using polycaprolactone sheets embedded with oxaliplatin (oxaliplatin sheets) and evaluated their therapeutic potential in murine models of colon and gastric cancers. Antitumor efficacy was compared with conventional intraperitoneal administration by monitoring tumor volume, body weight, and systemic oxaliplatin concentrations over 21 days, along with histopathological assessment of tumors and hepatic tissue. Oxaliplatin sheets demonstrated superior tumor suppression, significantly reduced Ki-67 positivity, and mitotic indices. Additionally, antitumor effects and blood oxaliplatin levels were consistent regardless of implantation site. Notably, oxaliplatin sheets significantly decreased weight loss compared with intraperitoneal administration. In our analysis of liver pathology, we found that hepatic sinusoidal obstruction and hepatocellular degeneration were significantly increased after intraperitoneal administration compared with untreated mice and mice treated with oxaliplatin sheets. Furthermore, treatment with oxaliplatin sheets improved survival. Thus, our oxaliplatin sheets exhibited effective tumor control and reduced side effects, indicating their potential as a promising treatment for advanced gastric and colorectal cancers.

権利情報:

キーワード: nanofibers, oxaliplatin, gastrointestinal cancer

刊行年月日: 2025-10-05

出版者: MDPI AG

掲載誌:

  • Nanomaterials (ISSN: 20794991) vol. 15 issue. 19 1524

研究助成金:

  • Japan Society for the Promotion of Science KAKENHI Grant-in-Aid for Scientific Research 21K08762
  • Grant-in-Aid for Transformative Research Areas 20H05877
  • Kansai Medical University

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.3390/nano15191524

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更新時刻: 2025-12-16 09:55:11 +0900

MDRでの公開時刻: 2025-12-19 14:11:44 +0900

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