# Degradation of a novel magnesium alloy-based bioresorbable coronary scaffold in a swine coronary artery model

https://mdr.nims.go.jp/datasets/6925d88a-77a5-46d6-9e16-6c51639cc83e

## File

- [CardiovascIntervTherapeutics39(2024)428-437.pdf](https://mdr.nims.go.jp/filesets/83677553-4221-434a-88d1-8a612e2b3ef1/download) ([Detail](https://mdr.nims.go.jp/filesets/83677553-4221-434a-88d1-8a612e2b3ef1.md))
- [CVIT2024_supplementary.docx](https://mdr.nims.go.jp/filesets/0ac91745-443d-4b4f-a81f-8912bdd96c0f/download) ([Detail](https://mdr.nims.go.jp/filesets/0ac91745-443d-4b4f-a81f-8912bdd96c0f.md))

## Id

6925d88a-77a5-46d6-9e16-6c51639cc83e

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-10-16T09:22:17.572437Z

## Updated at

2024-10-18T07:30:14.147574Z

## Published at

2024-10-18T07:30:15.583591Z

## Doi



## First published url

https://doi.org/10.1007/s12928-024-01023-3

## Date published

2024-07-22

## Recorded date published

2024-10

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Degradation of a novel magnesium alloy-based bioresorbable coronary scaffold
    in a swine coronary artery model
  title_type: original
  lang: en

## Description

- description: The objective of the study is to investigate the safety, feasibility,
    and degradation profile of a novel Mg alloy-based bioresorbable coronary scaffold
    (JFK-PRODUCT BRS) with thin struts (110 μm). Fourteen healthy pigs received 17
    JFK-PRODUCT BRSs in the coronary arteries and were sacrificed at 1, 6, 12, 18,
    and 26 months after implantation. Angiography, optical coherence tomography, microfocus
    X-ray computed tomography (μCT), scanning electron microscopy with energy-dispersive
    X-ray spectrometry (SEM–EDX), and histopathological evaluation were performed.
    The JFK-PRODUCT had a median percent late recoil of 11.28% at 1 month. The μCT
    observation confirmed that scaffold discontinuity reached 64.8% at 12 months with
    increased scaffold inner area thereafter, suggesting artery positive remodeling.
    The inflammation was mild, peaked at 18 months, and decreased thereafter. The
    SEM–EDX analysis demonstrated gradual degradation of the scaffold with formation
    of inorganic deposits, presumed to be calcium phosphates. It also revealed the
    disappearance of calcium phosphates at 26 months, achieving almost complete replacement
    of the scaffold by biocomponents.
  description_type: abstract
  lang: und

## Creator

- name: Sho Torii
  role: author
- name: Akiko Yamamoto
  role: author
  orcid: https://orcid.org/0000-0002-9182-4886
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Ayako Yoshikawa
  role: author
- name: Linhai Lu
  role: author
- name: Makoto Sasaki
  role: author
- name: Shoko Obuchi
  role: author
- name: Akira Wada
  role: author
- name: Hideo Tsukamoto
  role: author
- name: Gaku Nakazawa
  role: author
  orcid: https://orcid.org/0000-0002-6721-1342

## Contact agent



## Publisher

organization: Springer Science and Business Media LLC

## Managing organization



## Keyword

- subject: Percutaneous coronary intervention
  schema: not_defined
- subject: Bioabsorbable magnesium scaffolds
  schema: not_defined
- subject: Preclinical study
  schema: not_defined
- subject: Elemental mapping
  schema: not_defined
- subject: Controlled degradation profile
  schema: not_defined

## Rights

- description: "This article is licensed under a Creative Commons Attribution\r\n4.0
    International License, which permits use, sharing, adaptation,\r\ndistribution
    and reproduction in any medium or format, as long\r\nas you give appropriate credit
    to the original author(s) and the source,\r\nprovide a link to the Creative Commons
    licence, and indicate if changes\r\nwere made. The images or other third party
    material in this article are\r\nincluded in the article’s Creative Commons licence,
    unless indicated\r\notherwise in a credit line to the material. If material is
    not included in\r\nthe article’s Creative Commons licence and your intended use
    is not\r\npermitted by statutory regulation or exceeds the permitted use, you
    will\r\nneed to obtain permission directly from the copyright holder. To view
    a\r\ncopy of this licence, visit http://creativecommons.org/licenses/by/4.0/."
  identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Cardiovascular Intervention and Therapeutics
  issn: '18684300'
  volume: '39'
  issue: '4'
  start_page: 428
  end_page: 437

## Conference



## Related item



## Funding

- identifier: 18pc0101027h0001
  funder_name: AMED
  description: CiCLE

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 83677553-4221-434a-88d1-8a612e2b3ef1
  filename: CardiovascIntervTherapeutics39(2024)428-437.pdf
  content_type: application/pdf
  size: 3232935
  md5: e94e946082fbc7e73cd04b358b72d219
- id: 0ac91745-443d-4b4f-a81f-8912bdd96c0f
  filename: CVIT2024_supplementary.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 7261486
  md5: 4e3f356b92162c5e22765674a7973020

## Thumbnail

fileset_id: 83677553-4221-434a-88d1-8a612e2b3ef1
filename: CardiovascIntervTherapeutics39(2024)428-437.pdf