# Protein Separation and Purification Using Inorganic Oxide Materials: From Surface Chemistry to Biochemical Applications

https://mdr.nims.go.jp/datasets/64bda4b2-f1f5-4bb4-a815-e6eeecdcec51

## File

- [Protein separation and purification using inorganic oxide materials  from surface chemistry to biochemical applications.pdf](https://mdr.nims.go.jp/filesets/c334573b-8746-4b27-8486-f22c68a3708b/download) ([Detail](https://mdr.nims.go.jp/filesets/c334573b-8746-4b27-8486-f22c68a3708b.md))

## Id

64bda4b2-f1f5-4bb4-a815-e6eeecdcec51

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-07-17T04:49:12.366563Z

## Updated at

2026-07-17T06:01:01.802632Z

## Published at

2026-07-17T07:35:10.069765Z

## Doi

https://doi.org/10.48505/nims.6415

## First published url

https://doi.org/10.1080/14686996.2026.2701640

## Date published

2026-07-16

## Recorded date published



## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: 'Protein Separation and Purification Using Inorganic Oxide Materials: From
    Surface Chemistry to Biochemical Applications'
  title_type: original
  lang: en

## Description

- description: Inorganic oxide materials are widely used for protein and peptide separation
    because their surfaces support multiple types of interactions, including metal-centered
    coordination, electrostatic interactions, and both hydrophilic and hydrophobic
    interactions. This review summarizes the binding mechanisms between proteins/peptides
    and representative inorganic oxides – ZrO2, TiO2, SiO2, Fe3O4, Al2O3, ZnO, CeO2,
    SnO2, Nb2O5, Ta2O5, and Ga2O3. Particular emphasis is placed on the comparative
    analysis of adsorption mechanisms across these inorganic oxides and on factors
    such as crystal structure, surface acidity, and surface functionalization that
    influence adsorption selectivity. The review further discusses the effects of
    surface chemistry on purification performance and their combined effects on multi-step
    purification workflows. Recent advances in surface engineering and hybrid material
    design are highlighted to provide perspectives for the development of selective
    and mild protein purification processes. This framework offers guidance for the
    rational selection of inorganic oxide materials, enabling reproducible, selective,
    and mild purification of diverse proteins and peptides in biopharmaceutical applications.
  description_type: abstract
  lang: en

## Creator

- name: Shogo Kanoh
  role: author
  organization: National Institute of Advanced Industrial Science and Technology (AIST)
  department: a Research Institute of Core Technology for Materials Innovation
- name: Kentaro Shiraki
  role: author
- name: Katsuya Kato
  role: author
- name: Atsushi Hirano
  role: author

## Contact agent



## Publisher

organization: Taylor & Francis

## Managing organization



## Keyword

- subject: Inorganic oxides
  schema: not_defined
- subject: proteins
  schema: not_defined
- subject: peptides
  schema: not_defined
- subject: purification
  schema: not_defined
- subject: adsorption
  schema: not_defined
- subject: zirconia
  schema: not_defined
- subject: titania
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Science and Technology of Advanced Materials
  issn: '14686996'
  volume: '27'
  article_number: '2701640 '

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: c334573b-8746-4b27-8486-f22c68a3708b
  filename: Protein separation and purification using inorganic oxide materials  from
    surface chemistry to biochemical applications.pdf
  content_type: application/pdf
  size: 2046783
  md5: 62f5cda90b1aaf4b81110dfa956856bf

## Thumbnail

fileset_id: c334573b-8746-4b27-8486-f22c68a3708b
filename: Protein separation and purification using inorganic oxide materials  from
  surface chemistry to biochemical applications.pdf