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説明:

Inorganic oxide materials are widely used for protein and peptide separation because their surfaces support multiple types of interactions, including metal-centered coordination, electrostatic interactions, and both hydrophilic and hydrophobic interactions. This review summarizes the binding mechanisms between proteins/peptides and representative inorganic oxides – ZrO2, TiO2, SiO2, Fe3O4, Al2O3, ZnO, CeO2, SnO2, Nb2O5, Ta2O5, and Ga2O3. Particular emphasis is placed on the comparative analysis of adsorption mechanisms across these inorganic oxides and on factors such as crystal structure, surface acidity, and surface functionalization that influence adsorption selectivity. The review further discusses the effects of surface chemistry on purification performance and their combined effects on multi-step purification workflows. Recent advances in surface engineering and hybrid material design are highlighted to provide perspectives for the development of selective and mild protein purification processes. This framework offers guidance for the rational selection of inorganic oxide materials, enabling reproducible, selective, and mild purification of diverse proteins and peptides in biopharmaceutical applications.

権利情報:

• Creative Commons BY Attribution 4.0 International
  

キーワード: Inorganic oxides, proteins, peptides, purification, adsorption, zirconia, titania

刊行年月日: 2026-07-16

出版者: Taylor & Francis

掲載誌:

• Science and Technology of Advanced Materials (ISSN: 14686996) vol. 27 2701640

研究助成金:

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.6415

公開URL: https://doi.org/10.1080/14686996.2026.2701640

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更新時刻: 2026-07-17 15:01:01 +0900

MDRでの公開時刻: 2026-07-17 16:35:10 +0900