# Balancing strength, modulus, and biocompatibility in a novel oxygen-containing β-type titanium alloy

https://mdr.nims.go.jp/datasets/6409c7b4-7c57-42a2-868b-91ecb1345bd6

## File

- [JMaterResTech39(2025)7613-7625.pdf](https://mdr.nims.go.jp/filesets/ab4e79b0-ee80-4832-bfb4-1b6f2ce7b8d5/download) ([Detail](https://mdr.nims.go.jp/filesets/ab4e79b0-ee80-4832-bfb4-1b6f2ce7b8d5.md))
- [JMaterResTech39(2025)7613-7625_supplementary.docx](https://mdr.nims.go.jp/filesets/0a1f4849-25d9-429d-98cb-42e975358561/download) ([Detail](https://mdr.nims.go.jp/filesets/0a1f4849-25d9-429d-98cb-42e975358561.md))

## Id

6409c7b4-7c57-42a2-868b-91ecb1345bd6

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-11-17T08:21:39.320693Z

## Updated at

2025-11-18T03:30:09.615654Z

## Published at

2025-11-18T03:23:38.613986Z

## Doi



## First published url

https://doi.org/10.1016/j.jmrt.2025.11.120

## Date published

2025-11-17

## Recorded date published

2025-11

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Balancing strength, modulus, and biocompatibility in a novel oxygen-containing
    β-type titanium alloy
  title_type: original
  lang: en

## Description

- description: 'We report the development and evaluation of an oxygen-containing β-type
    titanium alloy, Ti–12Zr–6Nb–2Mo–2Sn–1.2O. X-ray diffraction confirmed single-phase
    β stability without martensitic transformation across annealing treatments (1173
    K, 60 s–1.8 ks). Texture and EBSD analyses revealed progressive weakening of the
    {110}〈001〉 with recovery and recrystallization. Tensile tests showed tunable responses:
    a favorable balance of low modulus (41 GPa) and high strength (>1000 MPa) at short
    annealing times, and increased ductility after prolonged annealing. Surface characterization
    indicated similar wettability and moderate roughness compared with cp-Ti; electrochemical
    tests confirmed stable passive-film formation and corrosion resistance. In vitro
    assays revealed enhanced fibroblast proliferation but reduced osteoblast adhesion
    relative to cp-Ti, indicating cell-type-dependent interactions. In vivo subcutaneous
    implantation in rats demonstrated tissue compatibility comparable to cp-Ti, with
    mild inflammation, successful regeneration, and normal hematopoiesis, albeit with
    slightly higher mast-cell degranulation. '
  description_type: abstract
  lang: und

## Creator

- name: Yazan Al-Zain
  role: author
  orcid: https://orcid.org/0000-0003-0088-6537
- name: Masanari Sakato
  role: author
- name: Akiko Yamamoto
  role: author
- name: Jihad M. AlAjlouni
  role: author
  orcid: https://orcid.org/0000-0002-1980-977X
- name: Mousa A. Al-Abbadi
  role: author
- name: Abdelkarim S. Aloweidi
  role: author
- name: Hee Young Kim
  role: author

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: β-Titanium alloy
  schema: not_defined
- subject: Texture evolution
  schema: not_defined
- subject: Ultralow elastic modulus
  schema: not_defined
- subject: Biocompatibility
  schema: not_defined
- subject: Orthopedic implants
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: Journal of Materials Research and Technology
  issn: '22387854'
  volume: '39'
  start_page: 7613
  end_page: 7625

## Conference



## Related item



## Funding

- identifier: '26249104'
  funder_name: Japan Society for the Promotion of Science
- identifier: 25K01521
  funder_name: Japan Society for the Promotion of Science KAKENHI

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: ab4e79b0-ee80-4832-bfb4-1b6f2ce7b8d5
  filename: JMaterResTech39(2025)7613-7625.pdf
  content_type: application/pdf
  size: 7173513
  md5: 7434b192e55b337e0ba34b9f5d28c3c6
- id: 0a1f4849-25d9-429d-98cb-42e975358561
  filename: JMaterResTech39(2025)7613-7625_supplementary.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 102289
  md5: 9f123a86af417e0878450bc2624b1446

## Thumbnail

fileset_id: ab4e79b0-ee80-4832-bfb4-1b6f2ce7b8d5
filename: JMaterResTech39(2025)7613-7625.pdf