# Differential intracellular influence of cancer cells and normal cells on magnetothermal properties and magnetic hyperthermal effects of magnetic nanoparticles

https://mdr.nims.go.jp/datasets/63ffa3b9-057e-451a-8ad6-e4902b752cea

## File

- [Wang-2025_Differential intracellular influence of cancer cells.pdf](https://mdr.nims.go.jp/filesets/e927d14b-50bc-4cdd-b6e1-d0255b518746/download) ([Detail](https://mdr.nims.go.jp/filesets/e927d14b-50bc-4cdd-b6e1-d0255b518746.md))
- [Supporting information-Wang-2025_Differential intracellular influence of cancer cells.pdf](https://mdr.nims.go.jp/filesets/277c566a-567b-426e-b624-c62f1a749589/download) ([Detail](https://mdr.nims.go.jp/filesets/277c566a-567b-426e-b624-c62f1a749589.md))

## Id

63ffa3b9-057e-451a-8ad6-e4902b752cea

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-07-10T06:42:56.236419Z

## Updated at

2025-07-18T23:30:23.695807Z

## Published at

2025-07-18T23:17:15.713107Z

## Doi



## First published url

https://doi.org/10.1039/d5mh00317b

## Date published

2025-03-14

## Recorded date published

2025-6-16

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Differential intracellular influence of cancer cells and normal cells on
    magnetothermal properties and magnetic hyperthermal effects of magnetic nanoparticles
  title_type: original
  lang: en

## Description

- description: This study unveiled for the first time the critical role of intracellular
    microenvironment on magnetic hyperthermia. The intracellular microenvironments
    of cancer cells and normal cells showed different influence on the magnetothermal
    properties and magnetic hyperthermia effects of magnetic nanoparticles (MNPs).
    The MNPs in cancer cells could generate higher temperatures and induce higher
    rates of apoptosis than those in normal cells. Compared with that of normal cells,
    the intracellular microenvironment of cancer cells was more conducive to Brownian
    relaxation and the dynamic magnetic response of internalized MNPs. The cancerous
    intracellular microenvironment had a discriminative effect on the magnetic hyperthermal
    effect of MNPs due to the low viscoelasticity of cancer cells, which was verified
    by the softening or stiffening of cells and simulation models created using viscous
    liquids or elastic hydrogels.
  description_type: abstract
  lang: eng

## Creator

- name: Man Wang
  role: author
  organization: National Institute for Materials Science
- name: Rui Sun
  role: author
  organization: National Institute for Materials Science
- name: Huajian Chen
  role: author
  orcid: https://orcid.org/0000-0003-1643-9782
  organization: National Institute for Materials Science
- name: Toru Yoshitomi
  role: author
  orcid: https://orcid.org/0000-0003-3847-1812
  organization: National Institute for Materials Science
- name: Hiroaki Mamiya
  role: author
  orcid: https://orcid.org/0000-0002-7840-3008
  organization: National Institute for Materials Science
- name: Masaki Takeguchi
  role: author
  orcid: https://orcid.org/0000-0002-0282-6020
  organization: National Institute for Materials Science
- name: Naoki Kawazoe
  role: author
  orcid: https://orcid.org/0000-0003-3916-0709
  organization: National Institute for Materials Science
- name: Yingnan Yang
  role: author
- name: Guoping Chen
  role: author
  orcid: https://orcid.org/0000-0001-6753-3678
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Royal Society of Chemistry (RSC)

## Managing organization



## Keyword

- subject: cancer cells
  schema: not_defined
- subject: magnetothermal properties
  schema: not_defined
- subject: magnetic hyperthermal effects
  schema: not_defined
- subject: magnetic nanoparticles
  schema: not_defined

## Rights

- identifier: cc-by-nc-3.0

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: MATERIALS HORIZONS
  issn: '20516347'
  volume: '12'
  issue: '12'
  start_page: 4363
  end_page: 4378

## Conference



## Related item



## Funding

- identifier: 19H04475
  funder_name: Japan Society for the Promotion of Science
- identifier: 21H03830
  funder_name: Japan Society for the Promotion of Science
- identifier: 22K19926
  funder_name: Japan Society for the Promotion of Science
- identifier: 24K03289
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: e927d14b-50bc-4cdd-b6e1-d0255b518746
  filename: Wang-2025_Differential intracellular influence of cancer cells.pdf
  content_type: application/pdf
  size: 8987023
  md5: 39c5f6e954398d245e1853295d31ae4f
- id: 277c566a-567b-426e-b624-c62f1a749589
  filename: Supporting information-Wang-2025_Differential intracellular influence
    of cancer cells.pdf
  content_type: application/pdf
  size: 2046208
  md5: 43992a79293b5cb05748a8427f3a7734

## Thumbnail

fileset_id: e927d14b-50bc-4cdd-b6e1-d0255b518746
filename: Wang-2025_Differential intracellular influence of cancer cells.pdf