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This study unveiled for the first time the critical role of intracellular microenvironment on magnetic hyperthermia. The intracellular microenvironments of cancer cells and normal cells showed different influence on the magnetothermal properties and magnetic hyperthermia effects of magnetic nanoparticles (MNPs). The MNPs in cancer cells could generate higher temperatures and induce higher rates of apoptosis than those in normal cells. Compared with that of normal cells, the intracellular microenvironment of cancer cells was more conducive to Brownian relaxation and the dynamic magnetic response of internalized MNPs. The cancerous intracellular microenvironment had a discriminative effect on the magnetic hyperthermal effect of MNPs due to the low viscoelasticity of cancer cells, which was verified by the softening or stiffening of cells and simulation models created using viscous liquids or elastic hydrogels.

権利情報:

• cc-by-nc-3.0
  

キーワード: cancer cells, magnetothermal properties, magnetic hyperthermal effects, magnetic nanoparticles

刊行年月日: 2025-03-14

出版者: Royal Society of Chemistry (RSC)

掲載誌:

• MATERIALS HORIZONS (ISSN: 20516347) vol. 12 issue. 12 p. 4363-4378

研究助成金:

• Japan Society for the Promotion of Science 19H04475
• Japan Society for the Promotion of Science 21H03830
• Japan Society for the Promotion of Science 22K19926
• Japan Society for the Promotion of Science 24K03289

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1039/d5mh00317b

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更新時刻: 2025-07-19 08:30:23 +0900

MDRでの公開時刻: 2025-07-19 08:17:15 +0900