# Detecting DNA translocation through a nanopore using a van der Waals heterojunction diode

https://mdr.nims.go.jp/datasets/62f6416f-d665-4eb3-ae50-09d24a8c604f

## File

- [chen-et-al-detecting-dna-translocation-through-a-nanopore-using-a-van-der-waals-heterojunction-diode.pdf](https://mdr.nims.go.jp/filesets/8eef21c6-172d-48de-ba20-7c4befda5e2f/download) ([Detail](https://mdr.nims.go.jp/filesets/8eef21c6-172d-48de-ba20-7c4befda5e2f.md))

## Id

62f6416f-d665-4eb3-ae50-09d24a8c604f

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-02-14T11:39:31.566139Z

## Updated at

2026-02-16T23:30:24.411391Z

## Published at

2026-02-16T09:00:50.934009Z

## Doi



## First published url

https://doi.org/10.1073/pnas.2422135122

## Date published

2025-05-06

## Recorded date published

2025-5-6

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Detecting DNA translocation through a nanopore using a van der Waals heterojunction
    diode
  title_type: original
  lang: en

## Description

- description: Conductive 2D membranes are attractive for nanopore sensing, as they
    simultaneously offer spatial resolution for interrogating a few nucleotides and
    the potential to integrate with wafer-scale circuits for low-noise measurements
    and multiplexing. Vertical 2D junctions exhibit an atomically sharp hetero-interface
    without a depletion region, opening new possibilities for biosensing. Here we
    present a novel nanopore sensing architecture in a dielectric-encapsulated vertical
    2D heterojunction diode of p-type WSe₂ on n-type MoS₂. The encapsulation allows
    robust operation while preserving spatial resolution down to a few nucleotides.
    We demonstrate that ionic potential modulates the heterojunction transport and,
    conversely, that heterojunction potential modulates ionic transport. Additionally,
    we achieve concurrent electrical and ionic sensing of DNA translocation, alongside
    electrical control of translocation speed. These findings establish a new paradigm
    for electrical DNA sensing and sequencing using solid-state nanopores.
  description_type: abstract
  lang: und

## Creator

- name: Sihan Chen
  role: author
- name: Siyuan Huang
  role: author
- name: Jangyup Son
  role: author
- name: Edmund Han
  role: author
- name: Kenji Watanabe
  role: author
  orcid: https://orcid.org/0000-0003-3701-8119
  organization: National Institute for Materials Science
- name: Takashi Taniguchi
  role: author
  orcid: https://orcid.org/0000-0002-1467-3105
  organization: National Institute for Materials Science
- name: Pinshane Y. Huang
  role: author
- name: William P. King
  role: author
- name: Arend M. van der Zande
  role: author
- name: Rashid Bashir
  role: author

## Contact agent



## Publisher

organization: Proceedings of the National Academy of Sciences

## Managing organization



## Keyword

- subject: DNA translocation
  schema: not_defined
- subject: 'nanopore
    '
  schema: not_defined
- subject: 'van der Waals heterojunction
    '
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/
  date_licensed: 2025-05-01

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Proceedings of the National Academy of Sciences
  issn: '00278424'
  volume: '122'
  issue: '18'
  article_number: e2422135122

## Conference



## Related item



## Funding

- identifier: '089401'
  funder_name: Taiwan Semiconductor Manufacturing Company
- identifier: '089401'
  funder_name: Taiwan Semiconductor Manufacturing Company
- identifier: R21HG010701
  funder_name: HHS | NIH | National Human Genome Research Institute
- identifier: R21HG010701
  funder_name: HHS | NIH | National Human Genome Research Institute
- identifier: '2309037'
  funder_name: NSF | MPS | Division of Materials Research
- identifier: 21H05233
  funder_name: MEXT | Japan Society for the Promotion of Science
- identifier: 21H05233
  funder_name: MEXT | Japan Society for the Promotion of Science
- identifier: 23H02052
  funder_name: MEXT | Japan Society for the Promotion of Science
- identifier: 23H02052
  funder_name: MEXT | Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Custom property



## Fileset

- id: 8eef21c6-172d-48de-ba20-7c4befda5e2f
  filename: chen-et-al-detecting-dna-translocation-through-a-nanopore-using-a-van-der-waals-heterojunction-diode.pdf
  content_type: application/pdf
  size: 2297114
  md5: 1b075832e0929389dcc1f43a17b0f3af

## Thumbnail

fileset_id: 8eef21c6-172d-48de-ba20-7c4befda5e2f
filename: chen-et-al-detecting-dna-translocation-through-a-nanopore-using-a-van-der-waals-heterojunction-diode.pdf