# Development of a Model System for Gas Cavity Formation Behavior of Magnesium Alloy Implantation

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## File

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## Id

607712b6-d6e5-4c0f-ba08-ba337bb95b98

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-01-24T07:44:54.225810Z

## Updated at

2024-01-25T00:50:26.714339Z

## Published at

2024-01-25T03:30:14.549924Z

## Doi



## First published url

https://doi.org/10.1021/acsbiomaterials.1c01429

## Date published

2022-06-13

## Recorded date published

2022-6-13

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Development of a Model System for Gas Cavity Formation Behavior of Magnesium
    Alloy Implantation
  title_type: original
  lang: en

## Description

- description: "Clinical applications of magnesium (Mg)-based screws have reported
    gas cavity formation in the surrounding tissue, which sometimes delays the fixation
    of the bone fracture. The gas cavity formation is considered to depend on the
    balance between hydrogen generation by Mg corrosion reacting with water in the
    body fluid and its diffusion into the surrounding tissue by capillary flow. In
    order to understand the gas cavity formation behavior by Mg-based material implantation,
    we developed a new in vitro model system to recreate this cavity formation phenomenon:
    the hydrogen generation by corrosion and its diffusion into the medium. A model
    tissue is prepared by gelation of the cell culture medium in a sterile condition.
    The immersion of Mg alloy samples was performed under 5% CO2 atmosphere with periodic
    observation by X-ray computed tomography, which enabled us to observe gas cavity
    growth up to 28 d. For demonstrating the usefulness of our model system, Mg alloy
    samples with different corrosion rates were prepared by a biodegradable polymer
    coating. AZ31 screws were spin-coated by poly-L-lactide (PLLA) and classified
    into three groups by their coating thickness as 1.0 ± 0.0, 1.6 ± 0.2, and 2.0
    ± 0.1 μm (ave. ± s.d.). Upon their immersion into the model tissue, the gas cavity
    volumes formed were 1.57 ± 0.23, 1.06 ± 0.22, and 0.38 ± 0.09 mm3/mm2 for 1.0,
    1.6, and 2.0 μm coating samples, having the weight loss of 20.2 ± 2.93, 18.5 ±
    2.84, and 11.3 ± 3.54 μg/mm2, respectively (ave. ± s.d.). This result clearly
    indicates the dependence of gas cavity formation on the corrosion rate of the
    sample. The gas cavity volume was only 3.3∼7.5% of the total hydrogen gas volume
    estimated based on the weight loss of the samples at 28 d, which is in the range
    of those calculated\r\nfrom the clinical report (3.2∼9.4% at 4w). This system
    can be an effective tool to investigate the gas cavity formation behavior and
    contribute to understand the mechanisms and controlling factors of this phenomenon."
  description_type: abstract
  lang: eng

## Creator

- name: Akiko Yamamoto
  role: author
  orcid: https://orcid.org/0000-0002-9182-4886
  organization: National Institute for Materials Science
- name: Akemi Kikuta
  role: author
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

## Managing organization



## Keyword

- subject: biodegradable metals
  schema: not_defined
- subject: magnesium alloys
  schema: not_defined
- subject: biocorrosion
  schema: not_defined
- subject: hydrogen gas
  schema: not_defined
- subject: in vitro evaluation
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: ACS Biomaterials Science & Engineering
  issn: '23739878'
  volume: '8'
  issue: '6'
  start_page: 2437
  end_page: 2444

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



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## Process for specimen treatment



## Computational method



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## Software



## Custom property



## Fileset

- id: 1d30ebdd-f63c-4eaa-bc26-5368ffb8204e
  filename: yamamoto-kikuta-2022-development-of-a-model-system-for-gas-cavity-formation-behavior-of-magnesium-alloy-implantation.pdf
  content_type: application/pdf
  size: 4390810
  md5: edd1f34f7841dab1860f73f90c411662
- id: cb891e06-cd7c-4e8a-b25a-e737be93909b
  filename: acsbiomaterials.1c01429_support_info.pdf
  content_type: application/pdf
  size: 22292
  md5: beec2239f6ee6fd1e6fc146aadd0324f

## Thumbnail

fileset_id: cb891e06-cd7c-4e8a-b25a-e737be93909b
filename: acsbiomaterials.1c01429_support_info.pdf