# Ultimately Adaptive Fluid Interfacial Phospholipid Membranes Unveiled Unanticipated High Cellular Mechanical Work

https://mdr.nims.go.jp/datasets/5f6ee568-9721-4612-aef0-433a5f228ea8

## File

- [adma202403396.pdf](https://mdr.nims.go.jp/filesets/3cbb5f8a-04d4-482c-9cb8-b3076c79e975/download) ([Detail](https://mdr.nims.go.jp/filesets/3cbb5f8a-04d4-482c-9cb8-b3076c79e975.md))

## Id

5f6ee568-9721-4612-aef0-433a5f228ea8

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-07-12T00:05:04.750813Z

## Updated at

2024-07-12T07:30:25.453780Z

## Published at

2024-07-12T07:30:25.539396Z

## Doi



## First published url

https://doi.org/10.1002/adma.202403396

## Date published

2024-04-29

## Recorded date published

2024-7

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Ultimately Adaptive Fluid Interfacial Phospholipid Membranes Unveiled Unanticipated
    High Cellular Mechanical Work
  title_type: original
  lang: en

## Description

- description: Living cells actively interact biochemically and mechanically with
    the surrounding extracellular matrices (ECMs) and undergo dramatic morphological
    and dimensional transitions, concomitantly remodeling ECMs. However, there is
    no suitable method to quantitatively discuss the contribution of mechanical interactions
    in such mutually adaptive processes. Herein, a highly deformable “living” cellular
    scaffold is developed to evaluate overall mechanical energy transfer between cell
    and ECMs. It is based on the water–perfluorocarbon interface decorated with phospholipids
    bearing a cell-adhesive ligand and fluorescent tag. The bioinert nature of the
    phospholipid membranes prevents the formation of solid-like protein nanofilms
    at the fluid interface, enabling to visualize and quantify cellular mechanical
    work against the ultimately adaptive model ECM. A new cellular wetting regime
    is identified, wherein interface deformation proceeds to cell flattening, followed
    by its eventual restoration. The cellular mechanical work during this adaptive
    wetting process is one order of magnitude higher than those reported with conventional
    elastic platforms. The behavior of viscous liquid drops at the air–water interface
    can simulate cellular adaptive wetting, suggesting that overall viscoelasticity
    of the cell body predominates the emergent wetting regime and regulates mechanical
    output. Cellular-force-driven high-energy states on the adaptive platform can
    be useful for cell fate manipulation.
  description_type: abstract
  lang: und

## Creator

- name: Zhou Lu
  role: author
- name: Mizuki Tenjimbayashi
  role: author
  orcid: https://orcid.org/0000-0002-8107-8285
  organization: National Institute for Materials Science
- name: Junhong Zhou
  role: author
  orcid: https://orcid.org/0000-0001-6327-6512
  organization: National Institute for Materials Science
- name: Jun Nakanishi
  role: author
  orcid: https://orcid.org/0000-0003-4457-6581
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: Mechanobiology
  schema: not_defined
- subject: Cell adhesion
  schema: not_defined
- subject: Fluid
  schema: not_defined
- subject: Viscoelasticity
  schema: not_defined
- subject: Wetting
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Advanced Materials
  issn: '09359648'
  volume: '36'
  issue: '27'

## Conference



## Related item



## Funding

- identifier: 21H01643
  funder_name: Japan Society for the Promotion of Science
- identifier: 22H00596
  funder_name: Japan Society for the Promotion of Science
- identifier: 23K17481
  funder_name: Japan Society for the Promotion of Science

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## Fileset

- id: 3cbb5f8a-04d4-482c-9cb8-b3076c79e975
  filename: adma202403396.pdf
  content_type: application/pdf
  size: 5366975
  md5: 7f4394c8dcc9f93000fb819a80d7be25

## Thumbnail

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filename: adma202403396.pdf