# Effect of hematoma on early degradation behavior of magnesium after implantation

https://mdr.nims.go.jp/datasets/5f5b5bd9-776b-4bab-9176-9cd264495e81

## File

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## Id

5f5b5bd9-776b-4bab-9176-9cd264495e81

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-28T06:37:42.533065Z

## Updated at

2024-08-30T23:30:56.556851Z

## Published at

2024-08-30T23:30:56.687042Z

## Doi



## First published url

https://doi.org/10.1088/1748-605x/ad7085

## Date published

2024-09-01

## Recorded date published

2024-9-1

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Effect of hematoma on early degradation behavior of magnesium after implantation
  title_type: original
  lang: en

## Description

- description: 'The corrosion of Mg-based bioabsorbable implanting devices is influenced
    by implantation environment which dynamically changes by biological response including
    wound healing. In this study, a hematoma model was created in a rat femur to analyze
    Mg corrosion with hematoma in the early stage of implantation. The results indicate
    that hematomas promote Mg corrosion and change the insoluble salt precipitation.
    The weight loss of the hematoma group was significantly larger than that of the
    non-hematoma group on day 7. In the non-hematoma group, carbonate and phosphate
    were detected even on day 1, but the only latter was detected on day 7. In the
    hematoma group, hydroxide was detected on day 1, followed by the formation of
    carbonate and phosphate on days 3 and 7. The obtained results suggest the hypoxic
    and acidic microenvironment in hematomas accelerates the Mg corrosion immediately
    after implantation, and the subsequent hematoma resorption process leads to the
    formation of phosphate and carbonate with organic molecules. This study revealed
    the risk of hematomas as an acceleration factor of the corrosion of Mg-based devices
    leading to the early implant failure. '
  description_type: abstract
  lang: und

## Creator

- name: Yu Yusa
  role: author
  orcid: https://orcid.org/0009-0009-1395-8182
- name: Yoshinaka Shimizu
  role: author
- name: Masanobu Hayashi
  role: author
- name: Takayuki Aizawa
  role: author
  orcid: https://orcid.org/0000-0002-6231-0368
- name: Takahiro Nakahara
  role: author
- name: Takahiro Ueno
  role: author
- name: Akimitsu Sato
  role: author
- name: Chieko Miura
  role: author
- name: Akiko Yamamoto
  role: author
  orcid: https://orcid.org/0000-0002-9182-4886
- name: Yoshimichi Imai
  role: author

## Contact agent



## Publisher

organization: IOP Publishing

## Managing organization



## Keyword

- subject: magnesium
  schema: not_defined
- subject: hematoma
  schema: not_defined
- subject: Raman analysis
  schema: not_defined
- subject: energy-dispersive x-ray spectroscopy
  schema: not_defined
- subject: insoluble salt
  schema: not_defined

## Rights

- description: "Original content from this work may be used under the terms of the\r\nCreative
    Commons Attribution 4.0 licence. Any further distribution of this work must maintain
    attribution to the author(s) and the title of the work, journal\r\ncitation and
    DOI."
  identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Biomedical Materials
  issn: '17486041'
  volume: '19'
  issue: '5'
  article_number: '055043'

## Conference



## Related item



## Funding

- funder_name: Nihon Parkerizing Co., Ltd
- identifier: 22H03988
  funder_name: Grants-in-Aid for Scientific Research

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 97549233-8286-4f58-9de9-5909454dfbb6
  filename: BiomedMater19(2024)055043.pdf
  content_type: application/pdf
  size: 2485365
  md5: 1c5961cc0aee824dc19033591029a9eb
- id: 2985dcad-599f-4b50-8ef4-408ccd267766
  filename: bmmad7085supp1.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 2484301
  md5: d09d1b0408df8b1db018ea490a5372fb

## Thumbnail

fileset_id: 97549233-8286-4f58-9de9-5909454dfbb6
filename: BiomedMater19(2024)055043.pdf