# Surface charge-dependent cytokine production using near-infrared emitting silicon quantum dots

https://mdr.nims.go.jp/datasets/5ce8d522-9536-4a1d-861a-8bd417ffbd10

## File

- [Scientific Reports 2024, 14, 9618.pdf](https://mdr.nims.go.jp/filesets/72357c1e-8371-4aa9-a61f-9b2f90c57476/download) ([Detail](https://mdr.nims.go.jp/filesets/72357c1e-8371-4aa9-a61f-9b2f90c57476.md))

## Id

5ce8d522-9536-4a1d-861a-8bd417ffbd10

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-04-30T05:12:26.611851Z

## Updated at

2024-04-30T23:30:14.370760Z

## Published at

2024-04-30T23:30:14.448225Z

## Doi



## First published url

https://doi.org/10.1038/s41598-024-60536-2

## Date published

2024-04-26

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Surface charge-dependent cytokine production using near-infrared emitting
    silicon quantum dots
  title_type: original
  lang: en

## Description

- description: This article outlines the preparation of three distinct surface-charged
    SiQDs-F127 (+0.03, + 9.13, -7.05 mV), varying from negative to positive charges.
    Depending on the surface charges, the amount of CpG ODNs also varies; positively
    charged materials take up more ODNs (-44.31 mV) than neutral (-37.10 mV) and negatively
    charged (-30.00 mV) materials due to electrostatic attraction. We assessed the
    viability of the cells, as well as their uptake and localization in endosomes.
    PSiQDs with a positive charge are more localized and induce higher levels of cytokines,
    including IL-6 and IFN-α, due to increased endosomal localization compared to
    other surface-charged PSiQDs. The results indicate that the surface charges of
    the nanoparticle play a significant role in delivering CpG ODN2006x3-PD and inducing
    cytokines.
  description_type: abstract
  lang: und

## Creator

- name: Shanmugavel Chinnathambi
  role: author
  orcid: https://orcid.org/0000-0001-9550-5367
- name: Naoto Shirahata
  role: author
  orcid: https://orcid.org/0000-0002-1217-7589
- name: Pooria Lesani
  role: author
- name: Vaijayanthi Thangavel
  role: author
- name: Ganesh N. Pandian
  role: author

## Contact agent



## Publisher

organization: Springer Science and Business Media LLC

## Managing organization



## Keyword

- subject: Colloidal Quantum dots
  schema: not_defined
- subject: Bioimaging
  schema: not_defined
- subject: Silicon nanocrystals
  schema: not_defined
- subject: CpG oligodeoxynucleotides
  schema: not_defined
- subject: Immune-stimulation
  schema: not_defined
- subject: Pluronic F127
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Scientific Reports
  issn: '20452322'
  volume: '14'
  article_number: '9618'

## Conference



## Related item



## Funding

- identifier: 22K19291
  funder_name: MEXT | Japan Society for the Promotion of Science
- identifier: 23H02607
  funder_name: MEXT | Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 72357c1e-8371-4aa9-a61f-9b2f90c57476
  filename: Scientific Reports 2024, 14, 9618.pdf
  content_type: application/pdf
  size: 8062383
  md5: cb7d9ccdd91732cea051ff0bb5d5b811

## Thumbnail

fileset_id: 72357c1e-8371-4aa9-a61f-9b2f90c57476
filename: Scientific Reports 2024, 14, 9618.pdf