# The century-old picture of a nerve spike is wrong: filaments fire, before membrane

https://mdr.nims.go.jp/datasets/5c742fc0-fd30-427b-a2be-ee512e6f7420

## File

- [The century-old picture of a nerve spike is wrong  filaments fire  before membrane.pdf](https://mdr.nims.go.jp/filesets/8a199fa4-d591-4bb9-bf28-f33720e1efd8/download) ([Detail](https://mdr.nims.go.jp/filesets/8a199fa4-d591-4bb9-bf28-f33720e1efd8.md))

## Id

5c742fc0-fd30-427b-a2be-ee512e6f7420

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-11-13T01:28:14.327120Z

## Updated at

2024-11-13T03:30:37.215980Z

## Published at

2024-11-13T03:30:37.287114Z

## Doi



## First published url

https://doi.org/10.1080/19420889.2022.2071101

## Date published

2022-12-31

## Recorded date published

2022-12-31

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: 'The century-old picture of a nerve spike is wrong: filaments fire, before
    membrane'
  title_type: original
  lang: en

## Description

- description: In 1907, Lapicque proposed that an electric field passes through the
    neuronal membrane and transmits a signal. Subsequently, a “snake curve” or spike
    was used to depict the means by which a linear flat current undergoes a sudden
    Gaussian or Laplacian peak. This concept has been the accepted scenario for more
    than 115 years even appearing in textbooks on the subject. It was not noted that
    the membrane spike should have a cylindrical shape. A nerve spike having a dot
    shape on membrane surface cannot propagate through a cylindrical surface since
    it would dissipate instantaneously. A nerve spike should have the appearance of
    a ring, encompassing the diameter of a cylindrical axon or dendron. However, this
    subtle change has remarkable implications. Maintaining a circular form of an electric
    field is not easy, especially at the surface of an organic object. Here, we suggest
    that neuroscience could redefine itself if we accept that a nerve spike is not
    a localized 3D Gaussian or Laplacian wave packet, rather it is a 3D ring encompassing
    the diameter of a neural branch.
  description_type: abstract
  lang: und

## Creator

- name: Subrata Ghosh
  role: author
- name: Pushpendra Singh
  role: author
  orcid: https://orcid.org/0000-0002-7274-6683
  organization: National Institute for Materials Science
- name: Jhimli Manna
  role: author
- name: Komal Saxena
  role: author
  organization: National Institute for Materials Science
- name: Pathik Sahoo
  role: author
  orcid: https://orcid.org/0000-0002-5102-9482
  organization: National Institute for Materials Science
- name: Soami Daya Krishnanda
  role: author
- name: Kanad Ray
  role: author
- name: Jonathan P. Hill
  role: author
  orcid: https://orcid.org/0000-0002-4229-5842
  organization: National Institute for Materials Science
- name: Anirban Bandyopadhyay
  role: author
  orcid: https://orcid.org/0000-0002-8823-4914
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Informa UK Limited

## Managing organization



## Keyword

- subject: nerve spike
  schema: not_defined
- subject: ion channel
  schema: not_defined
- subject: neuron
  schema: not_defined
- subject: neurophysiology
  schema: not_defined

## Rights

- description: This is an Open Access article distributed under the terms of the Creative
    Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which
    permits unrestricted use, distribution, and reproduction in any medium, provided
    the original work is properly cited.
  identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: Communicative & Integrative Biology
  issn: '19420889'
  volume: '15'
  issue: '1'
  start_page: 115
  end_page: 120

## Conference



## Related item



## Funding

- identifier: FA2386-16-1-0003 (2016–2019)
  funder_name: Asian Office of Aerospace Research and Development, [AOARD]

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 8a199fa4-d591-4bb9-bf28-f33720e1efd8
  filename: The century-old picture of a nerve spike is wrong  filaments fire  before
    membrane.pdf
  content_type: application/pdf
  size: 1968238
  md5: f8aa304d26c182a023655dd8a64d31cd

## Thumbnail

fileset_id: 8a199fa4-d591-4bb9-bf28-f33720e1efd8
filename: The century-old picture of a nerve spike is wrong  filaments fire  before
  membrane.pdf