# ChimericNanocurved Materials Reprogram Receptor Signalingto Induce Apoptosis via a Curvature-Sensing Protein

https://mdr.nims.go.jp/datasets/55105df7-7617-45b4-ba2e-a20935bcaa2c

## File

- [acsnano.6c00463.pdf](https://mdr.nims.go.jp/filesets/46245ac2-7629-4e78-8988-8b654d9924f6/download) ([Detail](https://mdr.nims.go.jp/filesets/46245ac2-7629-4e78-8988-8b654d9924f6.md))

## Id

55105df7-7617-45b4-ba2e-a20935bcaa2c

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-08-27T04:00:49.868487Z

## Updated at

2026-08-27T06:47:19.090626Z

## Published at

2026-08-27T09:27:17.353397Z

## Doi



## First published url

https://doi.org/10.1021/acsnano.6c00463

## Date published

2026-08-05

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: |-
    Chimeric
    Nanocurved Materials Reprogram Receptor Signaling
    to Induce Apoptosis via a Curvature-Sensing Protein
  title_type: original
  lang: en

## Description

- description: The nanoscale curvature of cell membranes plays a regulatory role in
    cell activity and response. This paper reports chimeric nanocurved materials functionalized
    with EGF that are capable of reprogramming growth factor signaling via a curvature-sensing
    protein. We achieved this by integrating epidermal growth factor (EGF) onto the
    surface of various nanostructured materials, which were exposed to the apical
    surface of cell membranes. These materials selectively triggered apoptosis, in
    contrast to flat EGF-modified surfaces. Serial variation of the nanoscopic parameters
    of the EGF-functionalized nanomaterials confirmed that the synergistic combination
    of the nanocurved material-mediated stimulation and receptor activation is critical
    for apoptosis induction. RNA-seq revealed a shift toward a pro-apoptotic gene
    expression profile, characterized by the suppression of survival-related pathways
    and enhancement of apoptosis-associated signals. Furthermore, gene editing experiments
    demonstrated that the nanocurved materials recruit the curvature-sensing protein
    PACSIN2, which in turn modulates the signaling cascade to induce apoptosis. Our
    findings show that chimeric nanocurved EGF-functionalized materials reprogram
    EGFR signaling from pro-survival to pro-apoptotic outcomes via an endocytosis-independent
    pathway mediated by PACSIN2. This mechanism underscores the potential of engineered
    biointerfaces to control receptor-mediated cell fate and suggests opportunities
    for patch-based anticancer therapies.
  description_type: abstract
  lang: und

## Creator

- name: Shota Yamamoto
  role: author
  orcid: https://orcid.org/0000-0002-7422-0968
- name: Naoki Fukata
  role: author
  orcid: https://orcid.org/0000-0002-0986-8485
- name: Wipakorn Jevasuwan
  role: author
  orcid: https://orcid.org/0000-0001-9117-2497
- name: Moritoshi Sato
  role: author
- name: Jun Nakanishi
  role: author
  orcid: https://orcid.org/0000-0003-4457-6581

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

## Managing organization



## Keyword

- subject: Nanostructures
  schema: not_defined
- subject: Apoptosis
  schema: not_defined
- subject: Epidermal growth factor
  schema: not_defined
- subject: BAR protein
  schema: not_defined
- subject: Cancer cell
  schema: not_defined
- subject: Mechanobiology
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: ACS Nano
  issn: '19360851'

## Conference



## Related item



## Funding

- identifier: 22K14705
  funder_name: Japan Society for the Promotion of Science
- identifier: 23K17481
  funder_name: Japan Society for the Promotion of Science
- identifier: 25K08712
  funder_name: Japan Society for the Promotion of Science

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## Chemical composition



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## Fileset

- id: 46245ac2-7629-4e78-8988-8b654d9924f6
  filename: acsnano.6c00463.pdf
  content_type: application/pdf
  size: 13182741
  md5: ae9cc4678736f10266031b4c2483634d

## Thumbnail

fileset_id: 46245ac2-7629-4e78-8988-8b654d9924f6
filename: acsnano.6c00463.pdf