# A facile, flexible, and multifunctional thermo-chemotherapy system for customized treatment of drug-resistant breast cancer

https://mdr.nims.go.jp/datasets/51c12088-1a70-4d1f-99f8-678aacefed97

## File

- [23_JCR.pdf](https://mdr.nims.go.jp/filesets/7ec4b7c0-8101-482f-93a2-e5c735513348/download) ([Detail](https://mdr.nims.go.jp/filesets/7ec4b7c0-8101-482f-93a2-e5c735513348.md))

## Id

51c12088-1a70-4d1f-99f8-678aacefed97

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-19T10:59:20.447797Z

## Updated at

2024-08-23T07:30:24.675014Z

## Published at

2024-08-23T07:30:25.166000Z

## Doi



## First published url

https://doi.org/10.1016/j.jconrel.2023.10.010

## Date published

2023-10-09

## Recorded date published

2023-11

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: A facile, flexible, and multifunctional thermo-chemotherapy system for customized
    treatment of drug-resistant breast cancer
  title_type: original
  lang: en

## Description

- description: Anticancer drug resistance invariably emerges and poses a significant
    barrier to curative therapy for various breast cancers. This results in a lack
    of satisfactory therapeutic medicine for cancer treatment. Herein, a universal
    vector system for drug-resistance breast cancer was designed to meet the needs
    of reversed multidrug resistance, thermo-chemotherapy, and long-term drug release
    behavior. The vector system comprises polycaprolactone (PCL) nanofiber mesh and
    magnetic nanoparticles (MNPs). PCL has excellent biocompatibility and electrospinning
    performance. In this study, MNPs were tailored to be thermogenic in response to
    an alternating magnetic field (AMF). PCL nanofiber can deliver various chemotherapy
    drugs, and suitable MNPs encapsulated in the nanofiber can generate hyperthermia
    and synergistic effect with those chemotherapy drugs. Therefore, a more personalized
    treatment system can be developed for different breast malignancies. In addition,
    the PCL nanofiber mesh (NFM) enables sustained release of the drugs for up two
    months, avoiding the burden on patients caused by repeated administration. Through
    model drugs doxorubicin (DOX) and chemosensitizers curcumin (CUR), we systematically
    verified the therapeutic effect of DOX-resistance breast cancer and inhibition
    of tumor generation in vivo. These findings represent a multifaceted platform
    of importance for validating strategic reversed MDR in pursuit of promoted thermo-chemotherapeutic
    outcomes. More importantly, the low cost and excellent safety and efficacy of
    this nanofiber mesh demonstrate that this can be customized multi-function vector
    system may be a promising candidate for refractory cancer therapy in clinical.
  description_type: abstract
  lang: und

## Creator

- name: Lili Chen
  role: author
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Ahmed Nabil
  role: author
- name: Nanami Fujisawa
  role: author
  orcid: https://orcid.org/0000-0002-8894-1790
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Emiho Oe
  role: author
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Kai Li
  role: author
  ror: https://ror.org/026v1ze26
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: nanofibers
  schema: not_defined
- subject: breast cancer
  schema: not_defined
- subject: chemotherapy
  schema: not_defined
- subject: hyperthermia
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Journal of Controlled Release
  issn: '01683659'
  volume: '363'
  start_page: 550
  end_page: 561

## Conference



## Related item



## Funding

- identifier: JP19H04476
  funder_name: Japan Society for the Promotion of Science
- identifier: JP20H05877
  funder_name: Japan Society for the Promotion of Science

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## Fileset

- id: 7ec4b7c0-8101-482f-93a2-e5c735513348
  filename: 23_JCR.pdf
  content_type: application/pdf
  size: 16203651
  md5: 1e584c99cd86678fc830f2f732c4657e

## Thumbnail

fileset_id: 7ec4b7c0-8101-482f-93a2-e5c735513348
filename: 23_JCR.pdf