A facile, flexible, and multifunctional thermo-chemotherapy system for customized treatment of drug-resistant breast cancer

Lili Chen; Ahmed Nabil; Nanami Fujisawa; Emiho Oe; Kai Li; Mitsuhiro Ebara

doi:10.1016/j.jconrel.2023.10.010

論文 A facile, flexible, and multifunctional thermo-chemotherapy system for customized treatment of drug-resistant breast cancer

Lili Chen (National Institute for Materials Science) ; Ahmed Nabil ; Nanami Fujisawa (National Institute for Materials Science) ; Emiho Oe (National Institute for Materials Science) ; Kai Li ; Mitsuhiro Ebara (National Institute for Materials Science)

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Lili Chen, Ahmed Nabil, Nanami Fujisawa, Emiho Oe, Kai Li, Mitsuhiro Ebara. A facile, flexible, and multifunctional thermo-chemotherapy system for customized treatment of drug-resistant breast cancer. Journal of Controlled Release. 2023, 363 (), 550-561. https://doi.org/10.1016/j.jconrel.2023.10.010

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(abstract)

Anticancer drug resistance invariably emerges and poses a significant barrier to curative therapy for various breast cancers. This results in a lack of satisfactory therapeutic medicine for cancer treatment. Herein, a universal vector system for drug-resistance breast cancer was designed to meet the needs of reversed multidrug resistance, thermo-chemotherapy, and long-term drug release behavior. The vector system comprises polycaprolactone (PCL) nanofiber mesh and magnetic nanoparticles (MNPs). PCL has excellent biocompatibility and electrospinning performance. In this study, MNPs were tailored to be thermogenic in response to an alternating magnetic field (AMF). PCL nanofiber can deliver various chemotherapy drugs, and suitable MNPs encapsulated in the nanofiber can generate hyperthermia and synergistic effect with those chemotherapy drugs. Therefore, a more personalized treatment system can be developed for different breast malignancies. In addition, the PCL nanofiber mesh (NFM) enables sustained release of the drugs for up two months, avoiding the burden on patients caused by repeated administration. Through model drugs doxorubicin (DOX) and chemosensitizers curcumin (CUR), we systematically verified the therapeutic effect of DOX-resistance breast cancer and inhibition of tumor generation in vivo. These findings represent a multifaceted platform of importance for validating strategic reversed MDR in pursuit of promoted thermo-chemotherapeutic outcomes. More importantly, the low cost and excellent safety and efficacy of this nanofiber mesh demonstrate that this can be customized multi-function vector system may be a promising candidate for refractory cancer therapy in clinical.

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