# Hierarchical Self-Assembly of Disulfide-Linked Single-Stranded DNA into Stimuli-Responsive Pods

https://mdr.nims.go.jp/datasets/513db3f1-a3c8-473f-89b5-a95959a89c12

## File

- [hierarchical-self-assembly-of-disulfide-linked-single-stranded-dna-into-stimuli-responsive-pods.pdf](https://mdr.nims.go.jp/filesets/2c78b48b-ba83-4623-9700-c6c1220dc38e/download) ([Detail](https://mdr.nims.go.jp/filesets/2c78b48b-ba83-4623-9700-c6c1220dc38e.md))

## Id

513db3f1-a3c8-473f-89b5-a95959a89c12

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-03-16T00:58:02.783147Z

## Updated at

2026-03-16T01:32:36.791071Z

## Published at

2026-03-16T08:54:57.151737Z

## Doi



## First published url

https://doi.org/10.1021/acs.chemmater.5c03128

## Date published

2026-02-24

## Recorded date published

2026-2-24

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Hierarchical Self-Assembly of Disulfide-Linked Single-Stranded DNA into Stimuli-Responsive
    Pods
  title_type: original
  lang: en

## Description

- description: Controlling the large-scale assembly of charged biopolymers is a fundamental
    challenge in materials chemistry. Here, we report a chemical strategy that uses
    disulfide-linked single-stranded DNA (ssDNA) dimers as unique building blocks
    to drive the hierarchical self-assembly of functional DNA microstructures. Formed
    from short, random-sequence oligomers, these dimers first organize into DNA-salt
    composite nanobead condensates, which then serve as scaffolds for the assembly
    of uniform, microrod-shaped DNA condensates called DNA-pods. The key innovation
    of this work is the material's unique, cooperative structural transition. Upon
    thermal stimulation (>60 °C), dsDNA-pods undergo a rapid exfoliation into an expanded
    ssDNA network, a process driven by significant gains in configurational entropy
    and the relief of electrostatic repulsion. This establishes a new, accessible
    strategy for creating stimuli-responsive DNA materials through a chemistry-driven,
    sequence-independent pathway. We further demonstrate that these materials act
    as robust host matrices for encapsulating guest molecules like doxorubicin.
  description_type: abstract
  lang: und

## Creator

- name: Volkan Kilinc
  role: author
- name: Linawati Sutrisno
  role: author
  orcid: https://orcid.org/0000-0003-3085-9660
  organization: National Institute for Materials Science
- name: Joel Henzie
  role: author
  orcid: https://orcid.org/0000-0002-9190-2645
  organization: National Institute for Materials Science
- name: Emmanuel Picheau
  role: author
  organization: National Institute for Materials Science
- name: Yusuke Yamauchi
  role: author
- name: Katsuhiko Ariga
  role: author
  orcid: https://orcid.org/0000-0002-2445-2955
  organization: National Institute for Materials Science
- name: Jonathan P. Hill
  role: author
  orcid: https://orcid.org/0000-0002-4229-5842
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

## Managing organization



## Keyword

- subject: Stimuli-responsive DNA pods
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/
  date_licensed: 2026-02-04

## Other identifier(s)



## Data origin



## Embargo



## Journal

- title: Chemistry of Materials
  issn: '15205002'
  volume: '38'
  issue: '4'
  start_page: 1968
  end_page: 1979

## Conference



## Related item



## Funding

- funder_name: Ministry of Education, Culture, Sports, Science and Technology
- identifier: JPMJER2003
  funder_name: Ministry of Education, Culture, Sports, Science and Technology
- funder_name: Australian National Fabrication Facility
- identifier: 20K05453
  funder_name: Ministry of Education, Culture, Sports, Science and Technology
- identifier: JP25H00898
  funder_name: Ministry of Education, Culture, Sports, Science and Technology

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 2c78b48b-ba83-4623-9700-c6c1220dc38e
  filename: hierarchical-self-assembly-of-disulfide-linked-single-stranded-dna-into-stimuli-responsive-pods.pdf
  content_type: application/pdf
  size: 14267093
  md5: 47f45c6c8a569211582d4e0a84b68455

## Thumbnail

fileset_id: 2c78b48b-ba83-4623-9700-c6c1220dc38e
filename: hierarchical-self-assembly-of-disulfide-linked-single-stranded-dna-into-stimuli-responsive-pods.pdf