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説明:

Controlling the large-scale assembly of charged biopolymers is a fundamental challenge in materials chemistry. Here, we report a chemical strategy that uses disulfide-linked single-stranded DNA (ssDNA) dimers as unique building blocks to drive the hierarchical self-assembly of functional DNA microstructures. Formed from short, random-sequence oligomers, these dimers first organize into DNA-salt composite nanobead condensates, which then serve as scaffolds for the assembly of uniform, microrod-shaped DNA condensates called DNA-pods. The key innovation of this work is the material's unique, cooperative structural transition. Upon thermal stimulation (>60 °C), dsDNA-pods undergo a rapid exfoliation into an expanded ssDNA network, a process driven by significant gains in configurational entropy and the relief of electrostatic repulsion. This establishes a new, accessible strategy for creating stimuli-responsive DNA materials through a chemistry-driven, sequence-independent pathway. We further demonstrate that these materials act as robust host matrices for encapsulating guest molecules like doxorubicin.

権利情報:

• Creative Commons BY Attribution 4.0 International
  

キーワード: Stimuli-responsive DNA pods

刊行年月日: 2026-02-24

出版者: American Chemical Society (ACS)

掲載誌:

• Chemistry of Materials (ISSN: 15205002) vol. 38 issue. 4 p. 1968-1979

研究助成金:

• Ministry of Education, Culture, Sports, Science and Technology
• Ministry of Education, Culture, Sports, Science and Technology JPMJER2003
• Australian National Fabrication Facility
• Ministry of Education, Culture, Sports, Science and Technology 20K05453
• Ministry of Education, Culture, Sports, Science and Technology JP25H00898

原稿種別: 出版者版 (Version of record)

MDR DOI:

公開URL: https://doi.org/10.1021/acs.chemmater.5c03128

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更新時刻: 2026-03-16 10:32:36 +0900

MDRでの公開時刻: 2026-03-16 17:54:57 +0900