# Functionalization of viscoelastic gels with decellularized extracellular matrix microparticles enhances tissue adhesion, cell spreading, and tissue regeneration

https://mdr.nims.go.jp/datasets/46e8606e-7a4e-4b80-af3b-2918834ecc26

## File

- [d5bm00394f.pdf](https://mdr.nims.go.jp/filesets/c41ccfa7-e70c-4b95-bf62-84be4056df5e/download) ([Detail](https://mdr.nims.go.jp/filesets/c41ccfa7-e70c-4b95-bf62-84be4056df5e.md))

## Id

46e8606e-7a4e-4b80-af3b-2918834ecc26

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-06-25T13:26:23.046758Z

## Updated at

2025-06-26T03:30:31.821722Z

## Published at

2025-06-26T03:26:34.099576Z

## Doi



## First published url

https://doi.org/10.1039/d5bm00394f

## Date published

2025-04-29

## Recorded date published

2025-6-25

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Functionalization of viscoelastic gels with decellularized extracellular
    matrix microparticles enhances tissue adhesion, cell spreading, and tissue regeneration
  title_type: original
  lang: en

## Description

- description: 'Natural extracellular matrix (ECM) is viscoelastic and fibrous, which
    are crucial characteristics for controlling cellular responses. In contrast, synthetic
    gels are mostly elastic and less effective at promoting mechanotransduction. Thus,
    design of gels that provide mechanical and biochemical cues for tissue regeneration
    need to be explored. In this study, we aimed to develop viscoelatic gels functionalized
    with decellularized ECM (dECM) microparticles for tissue regeneration. The incorporation
    of dECM microparticles into gels improved not only the tissue adhesive properties
    of the gels and but also their viscoelasticity. The modulation of the mechanical
    properties of the gels elicited cell adhesion and spreading. Moreover, the functionalization
    of viscoelastic gels with dECM microparticles promoted tissue regeneration in
    volumetric muscle-loss models. This approach would be powerful tool as functional
    scaffolds with sufficient mechanical and biological properties to facilitate tissue
    regeneration. '
  description_type: abstract
  lang: und

## Creator

- name: Debabrata Palai
  role: author
- name: Hana Yasue
  role: author
- name: Shima Ito
  role: author
  orcid: https://orcid.org/0000-0002-3233-617X
- name: Hiyori Komatsu
  role: author
  orcid: https://orcid.org/0000-0002-2525-1362
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530
- name: Akihiro Nishiguchi
  role: author
  orcid: https://orcid.org/0000-0002-3160-6385

## Contact agent



## Publisher

organization: Royal Society of Chemistry (RSC)

## Managing organization



## Keyword

- subject: Tissue regeneration
  schema: not_defined
- subject: Hydrogel
  schema: not_defined

## Rights

- identifier: cc-by-nc-3.0

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Biomaterials Science
  issn: '20474830'
  volume: '13'
  issue: '13'
  start_page: 3576
  end_page: 3584

## Conference



## Related item



## Funding

- identifier: 22H03962
  funder_name: Japan Society for the Promotion of Science
- identifier: 23H01718
  funder_name: Japan Society for the Promotion of Science
- identifier: 23K26411
  funder_name: Japan Society for the Promotion of Science
- identifier: 24K21677
  funder_name: Japan Society for the Promotion of Science
- funder_name: Uehara Memorial Foundation

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## Specimen



## Chemical composition



## Structure for specimen



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## Fileset

- id: c41ccfa7-e70c-4b95-bf62-84be4056df5e
  filename: d5bm00394f.pdf
  content_type: application/pdf
  size: 3225596
  md5: e395d01fcf62d620dda229d65b1c19f1

## Thumbnail

fileset_id: c41ccfa7-e70c-4b95-bf62-84be4056df5e
filename: d5bm00394f.pdf