# Physiomimetic Fluidic Culture Platform on Microwell-Patterned Porous Collagen Scaffold for Human Pancreatic Islets

https://mdr.nims.go.jp/datasets/3ba5aa6c-9801-4e72-8964-a4352eb33cf0

## File

- [kato-et-al-2024-physiomimetic-fluidic-culture-.pdf](https://mdr.nims.go.jp/filesets/54d7c57a-74f7-4124-a15a-e62d0d1337e6/download) ([Detail](https://mdr.nims.go.jp/filesets/54d7c57a-74f7-4124-a15a-e62d0d1337e6.md))

## Id

3ba5aa6c-9801-4e72-8964-a4352eb33cf0

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-05T05:28:55.250405Z

## Updated at

2024-08-05T07:30:28.565687Z

## Published at

2024-08-05T07:30:28.661689Z

## Doi



## First published url

https://doi.org/10.1177/09636897241249556

## Date published

2024-05-14

## Recorded date published

2024-1

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Physiomimetic Fluidic Culture Platform on Microwell-Patterned Porous Collagen
    Scaffold for Human Pancreatic Islets
  title_type: original
  lang: en

## Description

- description: 'Pancreatic islet transplantation is one of the clinical options for
    certain types of diabetes. However, difficulty in maintaining islets prior to
    transplantation limits the clinical expansion of islet transplantations. Our study
    introduces a dynamic culture platform developed specifically for primary human
    islets by mimicking the physiological microenvironment, including tissue fluidics
    and extracellular matrix support. We engineered the dynamic culture system by
    incorporating our distinctive microwell-patterned porous collagen scaffolds for
    loading isolated human islets, enabling vertical medium flow through the scaffolds.
    The physiological microenvironment-mimetic culture platform supported the viability
    and quality of isolated human islets at high-seeding density. '
  description_type: abstract
  lang: und

## Creator

- name: Hiroyuki Kato
  role: author
- name: Huajian Chen
  role: author
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Kuang-Ming Shang
  role: author
- name: Kenji Izumi
  role: author
- name: Naoya Koba
  role: author
- name: Takanori Tsuchiya
  role: author
- name: Naoki Kawazoe
  role: author
  orcid: https://orcid.org/0000-0003-3916-0709
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Janine Quijano
  role: author
- name: Keiko Omori
  role: author
- name: Chris Orr
  role: author
- name: Meirigeng Qi
  role: author
- name: Hsun Teresa Ku
  role: author
- name: Fouad Kandeel
  role: author
- name: Yu-Chong Tai
  role: author
- name: Guoping Chen
  role: author
  orcid: https://orcid.org/0000-0001-6753-3678
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Hirotake Komatsu
  role: author

## Contact agent



## Publisher

organization: SAGE Publications

## Managing organization



## Keyword

- subject: pancreatic islets
  schema: not_defined
- subject: collagen scaffold
  schema: not_defined
- subject: dynamic culture
  schema: not_defined
- subject: hypoxia
  schema: not_defined
- subject: physiomimetic culture
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Cell Transplantation
  issn: '09636897'
  volume: '33'
  start_page: 49556
  end_page: 49556
  article_number: '49556'

## Conference



## Related item



## Funding

- identifier: P30CA033572
  funder_name: National Institutes of Health
- identifier: R03DK129958-01
  funder_name: National Institutes of Health
- identifier: 22K19926
  funder_name: Japan Society for the Promotion of Science
- funder_name: Nora Eccles Treadwell Foundation
- identifier: 3-SRA-2021-1073-S-B
  funder_name: JDRF
- identifier: P30CA033572
  funder_name: National Cancer Institute of the National Institutes of Health

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 54d7c57a-74f7-4124-a15a-e62d0d1337e6
  filename: kato-et-al-2024-physiomimetic-fluidic-culture-.pdf
  content_type: application/pdf
  size: 7713698
  md5: 731c8d540b94ab15196114e9d6548e20

## Thumbnail

fileset_id: 54d7c57a-74f7-4124-a15a-e62d0d1337e6
filename: kato-et-al-2024-physiomimetic-fluidic-culture-.pdf