# Impact of Interfacial Viscosity on the Robustness of Phospholipid‐Decorated Fluid Cell Scaffolds

https://mdr.nims.go.jp/datasets/37d80649-4f40-4141-ad74-33f7c11c52f9

## File

- [Advanced NanoBiomed Research - 2025 - Zhou - Impact of Interfacial Viscosity on the Robustness of Phospholipid‐Decorated.pdf](https://mdr.nims.go.jp/filesets/fb70e74e-2939-46ae-a947-cc9c4a5d6171/download) ([Detail](https://mdr.nims.go.jp/filesets/fb70e74e-2939-46ae-a947-cc9c4a5d6171.md))

## Id

37d80649-4f40-4141-ad74-33f7c11c52f9

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-12-09T00:00:58.831957Z

## Updated at

2025-12-09T07:31:00.199949Z

## Published at

2025-12-09T07:26:05.804945Z

## Doi



## First published url

https://doi.org/10.1002/anbr.202500076

## Date published

2025-08-22

## Recorded date published

2025-11

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Impact of Interfacial Viscosity on the Robustness of Phospholipid‐Decorated
    Fluid Cell Scaffolds
  title_type: original
  lang: en

## Description

- description: The mechanical properties of the cellular microenvironment contribute
    significantly to cell behavior. Thus, deformable phospholipid-decorated perfluorocarbon
    interfaces have emerged for further expansion of material mechanics to an ultimate
    soft range as cell scaffolds. In addition, a highly deformable state requires
    the material to be robust enough to adapt to dynamic cellular forces. However,
    the effect of interfacial viscosity on the cell adhesion behavior and material
    robustness remains unknown on the super-soft substrate. To address these issues,
    an interfacial phospholipid membrane (IPLM) with tunable viscosity is constructed
    by varying the mixing ratio of saturated and unsaturated lipid layers. By co-assembling
    a cell adhesive and fluorescent lipid into the IPLM, it is shown that higher viscosity
    interfaces with lower unsaturated lipid content are preferred from the viewpoint
    of cell spreading. However, a viscosity that is too high for 0% unsaturated lipid
    alters the lipid layer to a brittle solid-like nature, making it less adaptive
    to cell traction-induced high deformation. Therefore, at least a trace amount
    of unsaturated lipids is required to maintain the robustness of fluid scaffolds.
    These findings are useful for the design of biomimetic materials and the long-term
    investigation of cell-matrix mechanical interactions in highly adaptive environments.
  description_type: abstract
  lang: und

## Creator

- name: Junhong Zhou
  role: author
  orcid: https://orcid.org/0000-0001-6327-6512
- name: Jun Nakanishi
  role: author
  orcid: https://orcid.org/0000-0003-4457-6581

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: Mechanobiology
  schema: not_defined
- subject: Fluid scaffold
  schema: not_defined
- subject: Viscosity
  schema: not_defined
- subject: Interface
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Advanced NanoBiomed Research
  issn: '26999307'
  volume: '5'
  issue: '11'
  article_number: '2500076'

## Conference



## Related item



## Funding

- identifier: 23K17481
  funder_name: Japan Society for the Promotion of Science
- identifier: 22H00596
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: fb70e74e-2939-46ae-a947-cc9c4a5d6171
  filename: Advanced NanoBiomed Research - 2025 - Zhou - Impact of Interfacial Viscosity
    on the Robustness of Phospholipid‐Decorated.pdf
  content_type: application/pdf
  size: 3460023
  md5: 02de9fb8b49ce710560425c93e17f498

## Thumbnail

fileset_id: fb70e74e-2939-46ae-a947-cc9c4a5d6171
filename: Advanced NanoBiomed Research - 2025 - Zhou - Impact of Interfacial Viscosity
  on the Robustness of Phospholipid‐Decorated.pdf