# Visualizing the Chronicle of Multiple Cell Fates using New Class of Near-IR Dual RNA/DNA Targeting Probe

https://mdr.nims.go.jp/datasets/367e06c6-a2c0-4271-88d5-9104cc715c15

## File

- [Poster.pdf](https://mdr.nims.go.jp/filesets/c423f3e5-9e72-4c02-8b38-3e8e5cae4be1/download) ([Detail](https://mdr.nims.go.jp/filesets/c423f3e5-9e72-4c02-8b38-3e8e5cae4be1.md))

## Id

367e06c6-a2c0-4271-88d5-9104cc715c15

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## Visibility

open_to_public

## State

published

## Created at

2025-10-27T06:44:13.278844Z

## Updated at

2025-11-04T23:30:03.623594Z

## Published at

2025-11-04T23:23:50.322607Z

## Doi

https://doi.org/10.48505/nims.5850

## First published url



## Date published



## Recorded date published



## Resource type

conference_poster

## Manuscript type

na

## Collection



## Title

- title: Visualizing the Chronicle of Multiple Cell Fates using New Class of Near-IR
    Dual RNA/DNA Targeting Probe
  title_type: original
  lang: en

## Description

- description: Early detection and late-stage cell fate assessment are key factors
    to develop therapeutic strategies, although current methods cannot capture early
    responses or distinguish multiple injury states, especially in UV-vis-sensitive
    cells. Here, we introduce a method to simultaneously detect variations in RNA
    and DNA under near-infrared photoexcitation. Utilizing a pyrazinacene-based probe
    (TEG8-N14), we unexpectedly achieved discrimination of multiple cell states, including
    apoptosis, necrosis, necroptosis, and senescence, based on RNA/DNA changes. Specifically,
    TEG8-N14 selectively stains necrotic cells in live samples, while after fixation,
    it allows detection of ultra-early senescence in UV-vis-sensitive cells, providing
    approximately two-fold greater informational content than existing RNA or DNA
    fluorophores. These findings break current imaging barriers by enabling comprehensive
    visualization of single-cell fate histories without being affected by UV-vis or
    genetic manipulation.
  description_type: abstract
  lang: eng

## Creator

- name: SUTRISNO Linawati
  role: author
  orcid: https://orcid.org/0000-0003-3085-9660
  organization: National Institute for Materials Science
  department: International Center for Young Scientists

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## Keyword

- subject: RNA/DNA
  schema: not_defined
- subject: imaging
  schema: not_defined
- subject: senescence
  schema: not_defined
- subject: N-heteroacene
  schema: not_defined
- subject: NIR
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

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## Data origin

- data_origin_type: other

## Embargo



## Journal



## Conference

name: The 1st Academic Conference on Bioinspired Materials Chemistry
start_date: 2025-10-17
end_date: 2025-10-20
identifier: https://www.chemsoc.org.cn/meeting/1SBMC/ <https://www.chemsoc.org.cn/meeting/1SBMC/

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## Funding

- identifier: JP24KF0089
  funder_name: JSPS
- identifier: JP25K23571
  funder_name: JSPS
- identifier: JP21K05044
  funder_name: JSPS
- identifier: DE220100163
  funder_name: 'Australian Research Council Discovery Early Career Award '

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## Fileset

- id: c423f3e5-9e72-4c02-8b38-3e8e5cae4be1
  filename: Poster.pdf
  content_type: application/pdf
  size: 2185022
  md5: 129e5f8eed62a0aa2e2a24085046b1d8

## Thumbnail

fileset_id: c423f3e5-9e72-4c02-8b38-3e8e5cae4be1
filename: Poster.pdf