Download file (2.03MB)
Download as zip (2MB)

コレクション

引用

説明:

In this study, the influence of viscosity on the adipogenic and osteogenic differentiation of human mesenchymal stem cells (hMSCs) was investigated by adjusting the viscosity of the culture medium. Viscosity exhibited different effects on adipogenic and osteogenic differentiation of hMSCs during two-dimensional (2D) culture. High viscosity facilitated osteogenic while inhibiting adipogenic differentiation. During adipogenic differentiation, the effect of viscosity on cell proliferation was negligible. However, during osteogenic differentiation, high viscosity decreased cell proliferation. The different influence of viscosity could be explained by the activation of mechanotransduction regulators of Yes-associated protein (YAP) and β-catenin. High viscosity could promote YAP and β-catenin nuclear translocation during osteogenic differentiation, which was responsible for the increased osteogenesis. High viscosity inhibited adipogenesis through promoting YAP nuclear translocation.

権利情報:

• In Copyright
  

キーワード: viscosity, adipogenic differentiation, osteogenic differentiation, mesenchymal stem cells

刊行年月日: 2024-09-24

出版者: Royal Society of Chemistry (RSC)

掲載誌:

• Biomaterials Science (ISSN: 20474830) vol. 12 issue. 21 p. 5598-5609

研究助成金:

• Japan Society for the Promotion of Science 21H03830
• Japan Society for the Promotion of Science 22K19926
• Japan Society for the Promotion of Science 24K03289

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.4897

公開URL: https://doi.org/10.1039/d4bm00710g

関連資料:

その他の識別子:

連絡先:

更新時刻: 2025-09-24 08:30:19 +0900

MDRでの公開時刻: 2025-09-24 08:23:28 +0900