# Smart composite scaffold to synchronize magnetic hyperthermia and chemotherapy for efficient breast cancer therapy

https://mdr.nims.go.jp/datasets/358ec0e9-feb1-4271-ad58-74764d71eff0

## File

- [Smart composite scaffold to synchronize magnetic hyperthermia and chemotherapy for efficient breast cancer therapy.docx](https://mdr.nims.go.jp/filesets/bf9e425d-7c5f-4925-b0de-ec33a2f34e41/download) ([Detail](https://mdr.nims.go.jp/filesets/bf9e425d-7c5f-4925-b0de-ec33a2f34e41.md))

## Id

358ec0e9-feb1-4271-ad58-74764d71eff0

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-10-09T01:53:03.293939Z

## Updated at

2026-02-20T03:30:33.621571Z

## Published at

2026-02-20T01:23:02.078747Z

## Doi

https://doi.org/10.48505/nims.4827

## First published url

https://doi.org/10.1016/j.biomaterials.2024.122511

## Date published

2024-02-20

## Recorded date published

2024-6

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Smart composite scaffold to synchronize magnetic hyperthermia and chemotherapy
    for efficient breast cancer therapy
  title_type: original
  lang: en

## Description

- description: Combination of different therapies is an attractive approach for cancer
    therapy. However, it is a challenge to synchronize different therapies for maximization
    of therapeutic effects. In this work, a smart composite scaffold that could synchronize
    magnetic hyperthermia and chemotherapy was prepared by hybridization of magnetic
    Fe3O4 nanoparticles and doxorubicin (Dox)-loaded thermosensitive liposomes with
    biodegradable polymers. Irradiation of alternating magnetic field (AMF) could
    not only increase the scaffold temperature for magnetic hyperthermia but also
    trigger the release of Dox for chemotherapy. The two functions of magnetic hyperthermia
    and chemotherapy were synchronized by switching AMF on and off. The synergistic
    anticancer effects of the composite scaffold were confirmed by in vitro cell culture
    and in vivo animal experiments. The composite scaffold could efficiently eliminate
    breast cancer cells under AMF irradiation. Moreover, the scaffold could support
    proliferation and adipogenic differentiation of mesenchymal stem cells for adipose
    tissue reconstruction after anticancer treatment. In vivo regeneration experiments
    showed that the composite scaffolds could effectively maintain their structural
    integrity and facilitate the infiltration and proliferation of normal cells within
    the scaffolds. The composite scaffold possesses multi-functions and is attractive
    as a novel platform for efficient breast cancer therapy.
  description_type: abstract
  lang: und

## Creator

- name: Rui Sun
  role: author
- name: Huajian Chen
  role: author
- name: Man Wang
  role: author
- name: Toru Yoshitomi
  role: author
  orcid: https://orcid.org/0000-0003-3847-1812
- name: Masaki Takeguchi
  role: author
  orcid: https://orcid.org/0000-0002-0282-6020
- name: Naoki Kawazoe
  role: author
  orcid: https://orcid.org/0000-0003-3916-0709
- name: Yingnan Yang
  role: author
- name: Guoping Chen
  role: author
  orcid: https://orcid.org/0000-0001-6753-3678

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: Fe3O4 nanoparticles
  schema: not_defined
- subject: Doxorubicin
  schema: not_defined
- subject: Thermosensitive liposomes
  schema: not_defined
- subject: Composite scaffolds
  schema: not_defined
- subject: Manetic hyperthermia
  schema: not_defined
- subject: Adipose tissue regeneration
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2024-02-20
end_date: 2026-02-20

## Journal

- title: Biomaterials
  issn: '01429612'
  volume: '307'
  article_number: '122511'

## Conference



## Related item



## Funding

- identifier: 19H04475
  funder_name: Japan Society for the Promotion of Science
- identifier: 21H03830
  funder_name: Japan Society for the Promotion of Science
- identifier: 22K19926
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Custom property



## Fileset

- id: bf9e425d-7c5f-4925-b0de-ec33a2f34e41
  filename: Smart composite scaffold to synchronize magnetic hyperthermia and chemotherapy
    for efficient breast cancer therapy.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 15966798
  md5: 2cc593659a0907faead75bdc85796e49

## Thumbnail

fileset_id: bf9e425d-7c5f-4925-b0de-ec33a2f34e41
filename: Smart composite scaffold to synchronize magnetic hyperthermia and chemotherapy
  for efficient breast cancer therapy.docx