# Molecular design of dynamically thermoresponsive biomaterials

https://mdr.nims.go.jp/datasets/2e6ca906-fcd6-4091-898a-9b4091af0226

## File

- [Molecular design of dynamically thermoresponsive biomaterials (1).pdf](https://mdr.nims.go.jp/filesets/1ed82b3d-a569-4f47-b16d-7fb5496afe1e/download) ([Detail](https://mdr.nims.go.jp/filesets/1ed82b3d-a569-4f47-b16d-7fb5496afe1e.md))

## Id

2e6ca906-fcd6-4091-898a-9b4091af0226

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-03-19T06:45:27.534905Z

## Updated at

2025-07-16T07:17:03.771768Z

## Published at

2025-03-26T08:26:40.306052Z

## Doi

https://doi.org/10.48505/nims.5375

## First published url

https://doi.org/10.1080/14686996.2025.2475736

## Date published

2025-12-31

## Recorded date published

2025-12-31

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Molecular design of dynamically thermoresponsive biomaterials
  title_type: original
  lang: en

## Description

- description: Dynamically thermoresponsive biomaterials, particularly those utilizing
    poly(N-isopropylacrylamide) (PNIPAAm), have attracted much attention in biomedical
    applications due to their reversible phase transition (32 °C) near body temperature.
    These biomaterials provide innovations across drug delivery system, chromatography,
    and tissue engineering. Molecular designs, such as the incorporation of hydrophilic
    comonomers or graft copolymers in PNIPAAm hydrogels, enhance rapid kinetics of
    the gels when jumping the temperature across the phase transition temperature,
    because of avoiding ‘skin layer’ formation on the surface of the gels. Nanocarriers
    possessing PNIPAAm coronas facilitate spatial drug delivery and temporally on-demand
    drug release to targeted cancers in combination with hyperthermic therapy. Downsizing
    of PNIPAAm hydrogels accelerates the kinetics of shrinkage/swelling, leading to
    applications as thermoresponsive chromatographic matrices and cell cultureware.
    PNIPAAm-modified surfaces support thermoresponsive cell culture systems for the
    non-invasive recovery of intact cell sheets, enabling advanced regenerative therapies
    and layered 3D tissue formation. Recent developments also integrate growth factor
    delivery for sustained cell stimulation on culturewares. Newly developed biomaterials,
    including dynamically thermoresponsive PNIPAAm, are expected to expand the opportunity
    for novel treatment technologies such as targeted therapies and regenerative medicine.
  description_type: abstract
  lang: en

## Creator

- name: Jun Kobayashi
  role: author
  organization: Tokyo Women’s Medical University, TWIns
  department: Institute of Advanced Biomedical Engineering and Science
- name: Masamichi Nakayama
  role: author
  organization: Tokyo Women’s Medical University, TWIns
  department: Institute of Advanced Biomedical Engineering and Science
- name: Kenichi Nagase
  role: author
  organization: Graduate School of Biomedical and Health Sciences, Hiroshima University

## Contact agent



## Publisher

organization: Taylor & Francis

## Managing organization



## Keyword

- subject: poly(N-isopropylacrylamide)
  schema: not_defined
- subject: chromatography
  schema: not_defined
- subject: bioseparation
  schema: not_defined
- subject: cell sheet
  schema: not_defined
- subject: regenerative medicine
  schema: not_defined
- subject: tissue engineering
  schema: not_defined
- subject: thermoresponsive polymer
  schema: not_defined
- subject: drug delivery system
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Science and Technology of Advanced Materials
  issn: '14686996'
  volume: '26'
  article_number: '2475736 '

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## Fileset

- id: 1ed82b3d-a569-4f47-b16d-7fb5496afe1e
  filename: Molecular design of dynamically thermoresponsive biomaterials (1).pdf
  content_type: application/pdf
  size: 5101668
  md5: 11d2a71d30cabb30ce95b5c4f3ea0058

## Thumbnail

fileset_id: 1ed82b3d-a569-4f47-b16d-7fb5496afe1e
filename: Molecular design of dynamically thermoresponsive biomaterials (1).pdf