# Scaffolds functionalized with matrix metalloproteinase-responsive release of miRNA for synergistic magnetic hyperthermia and sensitizing chemotherapy of drug-tolerant breast cancer

https://mdr.nims.go.jp/datasets/2d170a02-c939-42cc-881e-0f886cbac175

## File

- [Scaffolds functionalized with matrix metalloproteinase-responsive release.pdf](https://mdr.nims.go.jp/filesets/ff72cdbf-5f59-4434-b9c6-d398f958af34/download) ([Detail](https://mdr.nims.go.jp/filesets/ff72cdbf-5f59-4434-b9c6-d398f958af34.md))

## Id

2d170a02-c939-42cc-881e-0f886cbac175

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-10-25T01:11:00.506498Z

## Updated at

2024-10-25T07:30:53.775698Z

## Published at

2024-10-25T07:30:53.848193Z

## Doi



## First published url

https://doi.org/10.1016/j.bioactmat.2024.10.011

## Date published

2024-10-19

## Recorded date published

2025-2

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Scaffolds functionalized with matrix metalloproteinase-responsive release
    of miRNA for synergistic magnetic hyperthermia and sensitizing chemotherapy of
    drug-tolerant breast cancer
  title_type: original
  lang: en

## Description

- description: " In this study, multifunctional scaffolds were designed to efficiently
    treat drug-tolerant breast cancer by improving the sensitization of breast cancer
    cells and synchronizing anticancer drug release with magnetic hyperthermia. The
    scaffolds contained microRNA-encapsulated matrix metalloproteinase-cleavable liposomes,
    doxorubicin-encapsulated thermoresponsive liposomes and Fe3O4 nanoparticles. The
    scaffolds released microRNA specifically to improve the sensitization of breast
    cancer cells to anticancer drugs, and also showed excellent hyperthermia effects
    under alternating magnetic field irradiation. In vitro and in vivo studies demonstrated
    that the scaffolds effectively reduced drug resistance and eliminated doxorubicin-tolerant
    MDA-MB-231 cells through the synergistic effect of magnetic hyperthermia and sensitizing
    chemotherapy. Additionally, the scaffolds supported the proliferation and adipogenic
    differentiation of stem cells for adipose tissue regeneration after killing cancer. "
  description_type: abstract
  lang: und

## Creator

- name: Rui Sun
  role: author
- name: Man Wang
  role: author
- name: Tianjiao Zeng
  role: author
  orcid: https://orcid.org/0000-0002-1286-0337
- name: Huajian Chen
  role: author
- name: Toru Yoshitomi
  role: author
  orcid: https://orcid.org/0000-0003-3847-1812
- name: Masaki Takeguchi
  role: author
  orcid: https://orcid.org/0000-0002-0282-6020
- name: Naoki Kawazoe
  role: author
  orcid: https://orcid.org/0000-0003-3916-0709
- name: Yingnan Yang
  role: author
- name: Guoping Chen
  role: author
  orcid: https://orcid.org/0000-0001-6753-3678

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: Multifunctional scaffolds
  schema: not_defined
- subject: Magnetic hyperthermia
  schema: not_defined
- subject: Sensitizing chemotherapy
  schema: not_defined
- subject: Tissue regeneration
  schema: not_defined
- subject: Matrix metalloproteinase responsive
  schema: not_defined
- subject: microRNA encapsulated liposomes
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Bioactive Materials
  issn: 2452199X
  volume: '44'
  start_page: 205
  end_page: 219

## Conference



## Related item



## Funding

- identifier: 19H04475
  funder_name: Japan Society for the Promotion of Science
- identifier: 21H03830
  funder_name: Japan Society for the Promotion of Science
- identifier: 22K19926
  funder_name: Japan Society for the Promotion of Science
- identifier: 24K03289
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: ff72cdbf-5f59-4434-b9c6-d398f958af34
  filename: Scaffolds functionalized with matrix metalloproteinase-responsive release.pdf
  content_type: application/pdf
  size: 12752961
  md5: 4a227f8d34cb0ac7ebeb01b112d11e4a

## Thumbnail

fileset_id: ff72cdbf-5f59-4434-b9c6-d398f958af34
filename: Scaffolds functionalized with matrix metalloproteinase-responsive release.pdf