# Clay column chromatography for optical resolution: separation and asymmetric induction of cyclometalated iridium(III) complexes

https://mdr.nims.go.jp/datasets/2c4f666b-a2d9-4ed1-ba94-3d82d58ebacb

## File

- [(MDR) 2025_BSCJ_Clay Column Chromatography.pdf](https://mdr.nims.go.jp/filesets/2050ee2f-89dc-4a6b-9889-3676fb2e9038/download) ([Detail](https://mdr.nims.go.jp/filesets/2050ee2f-89dc-4a6b-9889-3676fb2e9038.md))

## Id

2c4f666b-a2d9-4ed1-ba94-3d82d58ebacb

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-12-24T10:05:47.522643Z

## Updated at

2026-04-30T03:01:11.491392Z

## Published at

2026-11-03T23:31:57.080948Z

## Doi

https://doi.org/10.48505/nims.6068

## First published url

https://doi.org/10.1093/bulcsj/uoaf110

## Date published

2025-10-29

## Recorded date published

2025-10-29

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: 'Clay column chromatography for optical resolution: separation and asymmetric
    induction of cyclometalated iridium(III) complexes'
  title_type: original
  lang: en

## Description

- description: Chromatographic separation was attempted by eluting iridium(III) complexes
    on a high-performance liquid chromatography (HPLC) column packed with an ion-exchange
    adduct of synthetic hectorite and -tris(1,10-phenanthroline)ruthenium(II). Affinity
    was adjusted by altering the loading of Δ-[Ru(phen)₃]²⁺ in the hectorite. Seven
    kinds of neutral iridium(III) complexes were resolved, with two peaks assigned
    to the Δ- and Λ- enantiomers. Three kinds of positively charged iridium(III) complexes
    were eluted, yielding Δ-enantiomers with optical purities of 60%−72% as less strongly
    adsorbed isomers. The opposite enantiomers were too firmly adsorbed for elution.
    When a five-coordinated iridium(III) complex (trans-[Ir(iPrBQ)₂Cl]) (iPrBQ = mono-deprotonated
    2-isopropylbenzo[h]quinoline), was injected, the entire complex was adsorbed and
    could not be eluted. Adding a negatively charged chelating ligand (disodium salt
    of 4,7-diphenylphenanthroline disulfate, Na₂BPS) eluted a negatively charged six-coordinated
    complex (trans-[Ir(iPrBQ)₂BPS]). The transformation from Δ- or Λ-trans-[Ir(iPrBQ)₂Cl]
    to trans-[Ir(iPrBQ)₂BPS]− occurred in the column. Notably, the eluted complex
    exclusively took the Δ-conformation from their ECD spectra. This is the first
    example of the stereoselective transformation of a coordinatively robust iridium(III)
    complex by passing it through a short column of 1 cm in length. The column uniquely
    afforded enantiomerically neutral, positively and negatively charged iridium(III)
    complexes.
  description_type: abstract
  lang: und

## Creator

- name: Akihiko Yamagishi
  role: author
- name: Kazuyoshi Takimoto
  role: author
  orcid: https://orcid.org/0000-0002-2969-6297
- name: Kyaw Naing
  role: author
- name: Kenji Tamura
  role: author
  orcid: https://orcid.org/0000-0001-6578-0923
- name: Masumi Kamon
  role: author
- name: Jun Yoshida
  role: author
- name: Hisako Sato
  role: author
  orcid: https://orcid.org/0000-0002-3927-1794

## Contact agent



## Publisher

organization: Oxford University Press (OUP)

## Managing organization



## Keyword

- subject: five-coordinated iridium(III) complexes
  schema: not_defined
- subject: stereoselective transformation
  schema: not_defined
- subject: vibrational circular dichroism spectroscopy
  schema: not_defined

## Rights

- description: 'This is a pre-copyedited, author-produced version of an article accepted
    for publication in Bulletin of the Chemical Society of Japan following peer review.
    The version of record Akihiko Yamagishi, Kazuyoshi Takimoto, Kyaw Naing, Kenji
    Tamura, Masumi Kamon, Jun Yoshida, Hisako Sato, Clay column chromatography for
    optical resolution: separation and asymmetric induction of cyclometalated iridium(III)
    complexes, Bulletin of the Chemical Society of Japan, Volume 98, Issue 11, November
    2025, uoaf110 is available online at: https://doi.org/10.1093/bulcsj/uoaf110.'
  identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2025-11-04
end_date: 2026-11-04

## Journal

- title: Bulletin of the Chemical Society of Japan
  issn: '00092673'
  volume: '98'
  issue: '11'
  article_number: uoaf110

## Conference



## Related item



## Funding

- identifier: JP17H03044
  funder_name: KAKENHI
- identifier: JP20K21090
  funder_name: KAKENHI
- identifier: JP22H02033
  funder_name: KAKENHI
- identifier: JP23K23301
  funder_name: KAKENHI
- identifier: JP23K13766
  funder_name: KAKENHI
- identifier: JP23K04783
  funder_name: KAKENHI

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 2050ee2f-89dc-4a6b-9889-3676fb2e9038
  filename: "(MDR) 2025_BSCJ_Clay Column Chromatography.pdf"
  content_type: application/pdf
  size: 1904743
  md5: 54acc2b835bcee428e424c0e6997a172

## Thumbnail

fileset_id: 2050ee2f-89dc-4a6b-9889-3676fb2e9038
filename: "(MDR) 2025_BSCJ_Clay Column Chromatography.pdf"