# Modifications of silicate bioglass synthesis and composition for in vitro dissolution control: Static and dynamic assessment

https://mdr.nims.go.jp/datasets/2bf9587a-a228-4128-8b98-539bd8bad8df

## File

- [Manuscript2_final.docx](https://mdr.nims.go.jp/filesets/7ead608a-8d8d-42b6-b46f-979268e55f67/download) ([Detail](https://mdr.nims.go.jp/filesets/7ead608a-8d8d-42b6-b46f-979268e55f67.md))

## Id

2bf9587a-a228-4128-8b98-539bd8bad8df

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-12-02T07:32:51.171712Z

## Updated at

2024-12-02T08:25:02.701315Z

## Published at

2026-10-10T23:20:50.484149Z

## Doi

https://doi.org/10.48505/nims.5077

## First published url

https://doi.org/10.1016/j.jnoncrysol.2024.123254

## Date published

2024-10-11

## Recorded date published

2024-12

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: 'Modifications of silicate bioglass synthesis and composition for in vitro
    dissolution control: Static and dynamic assessment'
  title_type: original
  lang: en

## Description

- description: A set of fifteen calcium-phosphate-silicate glass samples, varying
    in alkali, magnesium, silicon, and nitrogen content, was prepared, and their structural,
    thermal, and in vitro dissolution properties were analyzed. Infrared spectroscopy
    showed a high degree of depolymerization of the silicate network consisting mainly
    of Q2 and Q3 units. Thermal analysis showed that the silicon content primarily
    affects both the glass transition temperature and the thermal stability of the
    glasses. In vitro dissolution studies were conducted both in static and dynamic
    modes in phosphate-buffered saline. Greater weight loss can be observed for materials
    tested in the dynamic mode than in the static mode. Ion concentration profiles
    determined for PBS after immersing the glasses showed the release of sodium and
    calcium into solutions. Subsequent studies, conducted using scanning electron
    microscopy, X-ray diffraction, and infrared spectroscopy showed the formation
    of an amorphous or crystalline layer of calcium phosphates, most likely hydroxyapatite.
  description_type: abstract
  lang: und

## Creator

- name: Stefania Wolff
  role: author
- name: Sharafat Ali
  role: author
- name: Jakub Karczewski
  role: author
- name: Małgorzata Rutkowska
  role: author
- name: Hiroyo Segawa
  role: author
  orcid: https://orcid.org/0000-0002-7198-8410
- name: Natalia Anna Wójcik
  role: author
  orcid: https://orcid.org/0000-0001-7927-9187

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: bioglass
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2024-10-11
end_date: 2026-10-11

## Journal

- title: Journal of Non-Crystalline Solids
  issn: '00223093'
  volume: '646'
  article_number: '123254'

## Conference



## Related item



## Funding

- identifier: '87202002'
  funder_name: Lingnan Normal University
- identifier: 2023/07/X/ST3/00443
  funder_name: National Science Centre Poland
- identifier: '20220692'
  funder_name: Crafoord Foundation

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 7ead608a-8d8d-42b6-b46f-979268e55f67
  filename: Manuscript2_final.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 13235679
  md5: 585ee7a60eb3f0dad982585fa0fbd492

## Thumbnail

fileset_id: 7ead608a-8d8d-42b6-b46f-979268e55f67
filename: Manuscript2_final.docx