# Influence of Nucleation on Relaxation, Molecular Cooperativity, and Physical Stability of Celecoxib Glass

https://mdr.nims.go.jp/datasets/2aea965a-d1d4-4ba8-89ad-87db986936d5

## File

- [molpharm_CEL_final.docx](https://mdr.nims.go.jp/filesets/c507e9af-8f1b-4fba-81af-785ef40aa847/download) ([Detail](https://mdr.nims.go.jp/filesets/c507e9af-8f1b-4fba-81af-785ef40aa847.md))

## Id

2aea965a-d1d4-4ba8-89ad-87db986936d5

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-08-11T12:51:10.486407Z

## Updated at

2025-02-24T03:30:14.634660Z

## Published at

2025-02-24T03:30:15.739339Z

## Doi

https://doi.org/10.48505/nims.4687

## First published url

https://doi.org/10.1021/acs.molpharmaceut.3c01116

## Date published

2024-04-01

## Recorded date published

2024-4-1

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Influence of Nucleation on Relaxation, Molecular Cooperativity, and Physical
    Stability of Celecoxib Glass
  title_type: original
  lang: en

## Description

- description: 'Although nucleation is considered the first step in the crystallization
    of glass materials, the structure and properties of the nuclei are not understood
    well. Influence of nucleation on the structure and dynamics of celecoxib glass
    was evaluated in this study. The nuclei for Form III were induced by annealing
    the glass at freezing temperature, and their impact on the relaxation behavior
    was investigated using thermal analysis and broadband dielectric spectroscopy
    to find accelerated α relaxation and suppressed β relaxation. '
  description_type: abstract
  lang: und

## Creator

- name: Xue Han
  role: author
  orcid: https://orcid.org/0000-0003-4812-1410
  organization: National Institute for Materials Science
- name: Kexin Dai
  role: author
- name: Kohsaku Kawakami
  role: author
  orcid: https://orcid.org/0000-0002-3466-9365
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

## Managing organization



## Keyword

- subject: Glass
  schema: not_defined
- subject: Nucleation
  schema: not_defined
- subject: Crystallization
  schema: not_defined
- subject: Relaxation
  schema: not_defined
- subject: Cooperative rearranging region
  schema: not_defined

## Rights

- description: This document is the Accepted Manuscript version of a Published Work
    that appeared in final form in Molecular Pharmaceutics, copyright ©  2024 American
    Chemical Society after peer review and technical editing by the publisher. To
    access the final edited and published work see https://doi.org/10.1021/acs.molpharmaceut.3c01116
  identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2024-02-24
end_date: 2025-02-24

## Journal

- title: Molecular Pharmaceutics
  issn: '15438392'
  volume: '21'
  issue: '4'
  start_page: 1794
  end_page: 1803

## Conference



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## Instrument



## Instrument operator



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## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



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## Computational method



## Energy level/transition state



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## Custom property



## Fileset

- id: c507e9af-8f1b-4fba-81af-785ef40aa847
  filename: molpharm_CEL_final.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 2295516
  md5: 4369eb4e40ef6845bb491346d1378c1e

## Thumbnail

fileset_id: c507e9af-8f1b-4fba-81af-785ef40aa847
filename: molpharm_CEL_final.docx