# Improved hydration property of tissue adhesive/hemostatic microparticle based on hydrophobically-modified Alaska pollock gelatin

https://mdr.nims.go.jp/datasets/29c05707-3a29-4658-8428-c384cbb70e1f

## File

- [Supporting Information-R2.docx](https://mdr.nims.go.jp/filesets/0ba6c956-fc68-40a0-b880-3c84db30cd4a/download) ([Detail](https://mdr.nims.go.jp/filesets/0ba6c956-fc68-40a0-b880-3c84db30cd4a.md))
- [Manuscript-R2_Unmarked.docx](https://mdr.nims.go.jp/filesets/5d038760-34af-4a54-961f-052934f63152/download) ([Detail](https://mdr.nims.go.jp/filesets/5d038760-34af-4a54-961f-052934f63152.md))

## Id

29c05707-3a29-4658-8428-c384cbb70e1f

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-03-22T02:17:00.213353Z

## Updated at

2026-03-20T23:30:50.936707Z

## Published at

2026-03-20T12:43:04.164683Z

## Doi

https://doi.org/10.48505/nims.4449

## First published url

https://doi.org/10.1016/j.bioadv.2024.213834

## Date published

2024-03-19

## Recorded date published

2024-5

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Improved hydration property of tissue adhesive/hemostatic microparticle based
    on hydrophobically-modified Alaska pollock gelatin
  title_type: original
  lang: en

## Description

- description: The management of bleeding is an important aspect of endoscopic surgery
    to avoid excessive blood loss and minimize pain. In clinical settings, sprayable
    hemostatic particles are used for their easy delivery, adaptability to irregular
    shapes, and rapid hydration. However, conventional hemostatic particles present
    challenges associated with tissue adhesion, and they can also be displaced by
    blood flow. In a previous study, we introduced tissue adhesive microparticles
    (C10-sa-MPs) derived from Alaska pollock gelatin modified with decyl groups (C10-sa-ApGltn)
    that were modified with C10 groups linked via secondary amines. We established
    that C10-sa-MPs adhere to soft tissues through a hydration mechanism. However,
    their application as a hemostatic agent was limited by their long hydration times,
    which was attributed to their high hydrophobicity. In this study, we present a
    new microparticle type, C10-am-MPs, synthesized by incorporating decanoyl group
    modifications into ApGltn (C10-am-ApGltn), with C10 groups linked via amide bonds.
    C10-am-MPs exhibited enhanced hydration characteristics compared to C10-sa-MPs,
    attributed to superior water absorption facilitated by amide bonds rather than
    secondary amines. Furthermore, C10-am-MPs demonstrated comparable tissue adhesion
    properties and underwater adhesion stability to C10-sa-MPs. Notably, C10-am-MPs
    exhibited accelerated blood coagulation in vitro compared to C10-sa-MPs. The application
    of C10-am-MPs in an in vivo rat liver hemorrhage model resulted in a hemostatic
    effect comparable to a commercially available hemostatic particle. These findings
    highlight the potential utility of C10-am-MPs as an effective hemostatic agent
    for endoscopic procedures and surgical interventions.
  description_type: abstract
  lang: und

## Creator

- name: Shima Ito
  role: author
  orcid: https://orcid.org/0000-0002-3233-617X
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Kazuhiro Nagasaka
  role: author
- name: Hiyori Komatsu
  role: author
  orcid: https://orcid.org/0000-0002-2525-1362
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Debabrata Palai
  role: author
- name: Akihiro Nishiguchi
  role: author
  orcid: https://orcid.org/0000-0002-3160-6385
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: Endoscope submucosal dissection
  schema: not_defined
- subject: Bleeding
  schema: not_defined
- subject: Hemostatic agent
  schema: not_defined
- subject: Microparticles
  schema: not_defined
- subject: Tissue adhesion
  schema: not_defined
- subject: Underwater stability
  schema: not_defined
- subject: Hydrophobic interaction
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2024-03-19
end_date: 2026-03-20

## Journal

- title: Biomaterials Advances
  issn: '27729508'
  article_number: '213834'

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

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  filename: Supporting Information-R2.docx
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- id: 5d038760-34af-4a54-961f-052934f63152
  filename: Manuscript-R2_Unmarked.docx
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  md5: 790a52cbb32399e4bb4cb3f53a4d5795

## Thumbnail

fileset_id: 0ba6c956-fc68-40a0-b880-3c84db30cd4a
filename: Supporting Information-R2.docx