# Bridging the gap between in vitro and in vivo solubility-permeability interplay

https://mdr.nims.go.jp/datasets/29848b30-a949-45e5-add3-0e7013f3ee37

## File

- [manuscript_JPS_interplay.docx](https://mdr.nims.go.jp/filesets/6ff1f0b4-fcf1-4da6-818b-345f7a162064/download) ([Detail](https://mdr.nims.go.jp/filesets/6ff1f0b4-fcf1-4da6-818b-345f7a162064.md))

## Id

29848b30-a949-45e5-add3-0e7013f3ee37

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-04-30T01:20:16.797456Z

## Updated at

2025-10-22T23:30:07.591524Z

## Published at

2025-10-22T23:18:16.267277Z

## Doi

https://doi.org/10.48505/nims.5523

## First published url

https://doi.org/10.1016/j.xphs.2024.10.008

## Date published

2024-10-22

## Recorded date published

2025-1

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Bridging the gap between in vitro and in vivo solubility-permeability interplay
  title_type: original
  lang: en

## Description

- description: Use of solubilization carriers for poorly soluble drugs may disturb
    transmembrane absorption by lowering the activity of drug molecules, which is
    known as the solubility-permeability interplay. However, although many in vitro
    studies have indicated the negative impacts of use of solubilization carriers
    for oral absorption, in vivo studies that showed the interplay effect are limited.
    This study provides systematic in vitro, in situ, and in vivo investigation of
    the interplay effect of cyclodextrin using dexamethasone as a model drug. The
    evaluation methods included permeation through polymeric, artificial lipid, cell,
    and intestinal closed-loop membranes. Then, the results were compared with oral
    administration studies in mice and dogs. Although the interplay effect was clearly
    observed in the in vitro studies, no obvious interplay was found in the in vivo
    studies, suggesting that the interplay effect is more prominent in the in vitro
    permeation studies. Absence of in vivo interplay was attributed to the dilution
    effect in the gastrointestinal tract, interaction of the drug with living components,
    and clearance of the drug after membrane permeation. Overall, this investigation
    clearly demonstrated the applicability and limitations of in vitro permeation
    studies for predicting the interplay effects of solubilizers after the oral administration.
  description_type: abstract
  lang: und

## Creator

- name: Michinori Oikawa
  role: author
- name: Satoru Matsuura
  role: author
- name: Takeyuki Okudaira
  role: author
- name: Ryo Ito
  role: author
- name: Kanako Arima
  role: author
- name: Masahiro Fushimi
  role: author
- name: Takamasa Oda
  role: author
- name: Kaoru Ohyama
  role: author
- name: Kohsaku Kawakami
  role: author
  orcid: https://orcid.org/0000-0002-3466-9365

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: Solubility-permeability interplay
  schema: not_defined
- subject: Solubilization
  schema: not_defined
- subject: Poorly soluble drug
  schema: not_defined
- subject: Oral absorption
  schema: not_defined
- subject: Cyclodextrin
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2024-10-22
end_date: 2025-10-22

## Journal

- title: Journal of Pharmaceutical Sciences
  issn: '00223549'
  volume: '114'
  issue: '1'
  start_page: 361
  end_page: 370

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## Fileset

- id: 6ff1f0b4-fcf1-4da6-818b-345f7a162064
  filename: manuscript_JPS_interplay.docx
  content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
  size: 1264048
  md5: e33ea3474341e49bd5180c7386803945

## Thumbnail

fileset_id: 6ff1f0b4-fcf1-4da6-818b-345f7a162064
filename: manuscript_JPS_interplay.docx