# Enhancement of copper antiviral activity with glutathione treatment

https://mdr.nims.go.jp/datasets/282642c6-0793-445e-ab71-213a55855e16

## File

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- [SupplementaryMaterials2_final.pdf](https://mdr.nims.go.jp/filesets/67b4465f-9e14-45f7-9d4f-6d1c61de1df7/download) ([Detail](https://mdr.nims.go.jp/filesets/67b4465f-9e14-45f7-9d4f-6d1c61de1df7.md))

## Id

282642c6-0793-445e-ab71-213a55855e16

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-06-24T05:20:17.683670Z

## Updated at

2026-06-24T06:35:04.587564Z

## Published at

2026-06-24T09:27:30.433474Z

## Doi



## First published url

https://doi.org/10.1021/acsabm.6c00520

## Date published



## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Enhancement of copper antiviral activity with glutathione treatment
  title_type: original
  lang: en

## Description

- description: "Copper and its alloys have antimicrobial activity effective for various
    pathogens. Their application to touch surface successfully reduced bioburden in
    hospital intensive care units but failed to completely prevent the transmission
    of pathogens derived from the hospital room. Discoloration of pure copper with
    surface oxide growth is another issue to discourage its application to touch surface.
    Common copper alloys have relatively high resistance for discoloration, but their
    antimicrobial activity is lower than that of pure copper. Therefore, enhancement
    of the antimicrobial activity of copper alloys is beneficial for their touch surface
    application. In this study, glutathione was employed for surface treatment of
    copper and its alloys to enhance their antiviral activity. Treatment with 4mM
    of glutathione in 99vol.% ethanol-1% H2O markedly enhanced copper and its alloys’
    antiviral activities against bacteriophage Qβ except MONEL, which has the lowest
    Cu content (33.4 wt.%). Electrochemical impedance measurement under thin electrolyte
    film revealed acceleration of copper and its alloys’ corrosion by the glutathione
    treatment. The antiviral activity of tested materials with the glutathione treatment
    correlated well with their corrosion rate, except MONEL. Potentiodynamic and chronopotentiometry
    measurements in 6 M KOH + 1 M LiOH demonstrated reduction in the thickness of
    surface oxide layer by the glutathione treatment. These facts suggest that the
    glutathione treatment reduces surface oxide layer, resulting in acceleration of
    corrosion with increase in Cu ion release which enhances\r\nantiviral activity."
  description_type: abstract
  lang: eng

## Creator

- name: Akiko Yamamoto
  role: author
  orcid: https://orcid.org/0000-0002-9451-8147
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Bioceramics
    Group
- name: Yasushi Suetsugu
  role: author
  orcid: https://orcid.org/0000-0002-8161-1908
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Biomaterials Field/Bioceramics
    Group

## Contact agent



## Publisher

organization: American Chemical Society (ACS)
ror: https://ror.org/

## Managing organization



## Keyword

- subject: antiviral tests
  schema: not_defined
- subject: copper alloys
  schema: not_defined
- subject: " glutathione"
  schema: not_defined
- subject: electrochemical impedance spectroscopy
  schema: not_defined
- subject: bacteriophage Qβ
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: ACS Applied Bio Materials
  issn: '25766422'
  volume: '9'
  issue: '12'
  start_page: 5237
  end_page: 5248

## Conference



## Related item



## Funding

- identifier: " JPMJTM20KSPS"
  funder_name: JST
  description: A-STEP

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: eb0c3642-ccb6-487b-9e52-fd69db770a55
  filename: ACSApplBioMater9(2026)5237-5248.pdf
  content_type: application/pdf
  size: 1906791
  md5: 585ce6d75509a15c7e133766b1e7f8d0
- id: 67b4465f-9e14-45f7-9d4f-6d1c61de1df7
  filename: SupplementaryMaterials2_final.pdf
  content_type: application/pdf
  size: 602345
  md5: d08b570ddae1e97d816c60531d659ee0

## Thumbnail

fileset_id: eb0c3642-ccb6-487b-9e52-fd69db770a55
filename: ACSApplBioMater9(2026)5237-5248.pdf