# Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura in rat long‑term study after 2‑week intra‑tracheal intrapulmonary administration

https://mdr.nims.go.jp/datasets/25662f7c-7623-4991-ba08-b17b31f4fccd

## Files

- [C60NWs_not carcinogenic_AT24.pdf](https://mdr.nims.go.jp/filesets/208f2fde-2ff2-4169-b670-4f6dff672595/download) ([Detail](https://mdr.nims.go.jp/filesets/208f2fde-2ff2-4169-b670-4f6dff672595.md))

## Id

25662f7c-7623-4991-ba08-b17b31f4fccd

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-09-20T01:06:52.445314Z

## Updated at

2024-11-06T01:46:23.459093Z

## Published at

2024-09-20T07:30:24.164242Z

## Doi



## First published url

https://doi.org/10.1007/s00204-024-03863-7

## Date published

2024-09-13

## Recorded date published

2024-12

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Fullerene and fullerene whisker are not carcinogenic to the lungs and pleura
    in rat long‑term study after 2‑week intra‑tracheal intrapulmonary administration
  title_type: original
  lang: en

## Description

- description: "Fullerene whiskers (FLW)s are thin rod-like structures composed of
    C60\r\nand C70 fullerene (FL). The shape of FLWs suggests potential toxic effects
    including carcinogenicity to the lung and pleura, similar to effects elicited
    by asbestos and multiwalled carbon nanotubes (MWCNT)s. However, no long-term carcinogenic
    studies of FL or FLW have been conducted. In the present study we investigated
    the pulmonary and pleural carcinogenicity of FL and FLW. Twelve-week-old male
    F344 rats were administered 0.25 or 0.5 mg FL, FLW, MWCNT-7, and MWCNT-N by intra-tracheal
    intra-pulmonary spraying\r\n(TIPS). Acute lung lesions and carcinogenicity were
    analyzed at 1 and 104 weeks after 8 doses/15 days TIPS administration. At week
    1, FLW, MWCNT-7, and MWCNT-N significantly increased alveolar macrophage infiltration.
    Expression of Ccl2 and Ccl3, reactive oxygen species production, and cell proliferation
    were significantly increased by administration of MWCNT-7 and MWCNT-N but not
    FL or FLW. At week 104, the incidence of bronchiolo-alveolar adenoma plus adenocarcinoma
    was significantly increased in the MWCNT-7 and MWCNT-N groups, and the incidence
    of mesothelioma was significantly increased in the MWCNT-7 group. No significant
    induction of pulmonary or pleural tumorigenesis was observed in the FL or FLW
    groups. The number of 8-OHdG-positive cells in the alveolar epithelium was significantly
    increased in the MWCNT-7 and MWCNT-N groups but not in the FL or FLW groups. FL
    and FLW did not exert pulmonary or pleural\r\ncarcinogenicity in our study. In
    addition, oxidative DNA damage was implicated in MWCNT-induced lung carcinogenesis,suggesting
    that it may be a useful initial marker of carcinogenicity."
  description_type: abstract
  lang: eng

## Creator

- name: Asraful Nahar Sheema
  role: author
- name: Aya Naiki-Ito
  role: author
  orcid: https://orcid.org/0000-0003-0828-2033
- name: Anna Kakehashi
  role: author
- name: Omnia Hosny Mohamed Ahmed
  role: author
- name: David B. Alexander
  role: author
- name: William T. Alexander
  role: author
- name: Takamasa Numano
  role: author
- name: Hiroyuki Kato
  role: author
- name: Yuko Goto
  role: author
- name: Hiroshi Takase
  role: author
- name: Akihiko Hirose
  role: author
- name: Takatsugu Wakahara
  role: author
  orcid: https://orcid.org/0000-0002-6365-3215
- name: Kun’ichi Miyazawa
  role: author
- name: Satoru Takahashi
  role: author
- name: Hiroyuki Tsuda
  role: author

## Contact agent



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## Keyword

- subject: fullerene whisker
  schema: not_defined
- subject: Fullerene
  schema: not_defined
- subject: not carcinogenic
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: ARCHIVES OF TOXICOLOGY
  issn: '14320738'
  volume: '98'

## Conference



## Related item



## Funding

- identifier: JPMH20316858
  funder_name: Ministry of Health, Labour and Welfare
- identifier: JPMH16769893
  funder_name: Ministry of Health, Labour and Welfare

## Instrument



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## Specimen



## Chemical composition



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## Fileset

- id: 208f2fde-2ff2-4169-b670-4f6dff672595
  filename: C60NWs_not carcinogenic_AT24.pdf
  content_type: application/pdf
  size: 12974180
  md5: 46d534c811ba6b1def6ba8028b4d8c23

## Thumbnail

fileset_id: 208f2fde-2ff2-4169-b670-4f6dff672595
filename: C60NWs_not carcinogenic_AT24.pdf