# Macrophage targeting precision nanomedicine utilizing ROS-responsive metallozyme-loaded nanomicelle for enhanced treatment of gout-induced inflammation

https://mdr.nims.go.jp/datasets/23d86756-f0e8-4a15-9d66-75178f4996a8

## File

- [Macrophage targeting precision nanomedicine utilizing ROS-responsive metallozyme-loaded nanomicelle for enhanced treatment of gout-induced inflammatio.pdf](https://mdr.nims.go.jp/filesets/d669f9a5-e544-47bc-99e9-c9a142c1cd1a/download) ([Detail](https://mdr.nims.go.jp/filesets/d669f9a5-e544-47bc-99e9-c9a142c1cd1a.md))

## Id

23d86756-f0e8-4a15-9d66-75178f4996a8

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-04-24T02:53:45.896426Z

## Updated at

2025-07-16T07:14:51.741361Z

## Published at

2025-04-24T07:22:39.522435Z

## Doi

https://doi.org/10.48505/nims.5452

## First published url

https://doi.org/10.1080/14686996.2025.2491304

## Date published

2025-12-31

## Recorded date published

2025-12-31

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Macrophage targeting precision nanomedicine utilizing ROS-responsive metallozyme-loaded
    nanomicelle for enhanced treatment of gout-induced inflammation
  title_type: original
  lang: en

## Description

- description: The excessive accumulation of monosodium urate crystals in joints leads
    to the pathological condition known as gout. While conventional treatments, which
    include Non-steroidal Anti-inflammatory Drugs, are available, their short half-life
    and low bioavailability limit their practical application. To overcome these limitations
    and leverage the Reactive Oxygen Species (ROS)-rich microenvironment, this study
    developed a novel ROS-responsive thioketal-linked hyaluronic acid-based micelle
    loaded with manganese oxide (HTO-MnO) for enhanced treatment. Following the synthesis
    of the HTO-MnO nanocomplex, the micelle was well characterized and the synthesized
    micelle were subjected to multiple tests to confirm their efficacy in reducing
    ROS. In addition, the in-vitro treatment of M1-polarized macrophages showed significant
    responses at both the gene and protein expression levels. Eventually, in-vivo
    analysis of the HTO-MnO nanoparticles was performed in the MSU-induced arthritis
    mouse model. The elevated ROS levels in the ankle joint of the mice triggered
    the release of MnO nanoparticles from the HTO micelles, suppressing the ROS levels
    and repolarizing macrophages to their M0 state, thereby effectively mitigating
    inflammation. This study demonstrates the potential of nanocomplex to reduce ankle
    swelling and intrinsic ROS levels by targeting M1 macrophages. The results highlight
    its precise therapeutic mechanism to alleviate inflammation and treat gouty arthritis.
  description_type: abstract
  lang: en

## Creator

- name: Padmanaban Sathiyamoorthy
  role: author
  organization: Chonnam National University Medical School
  department: a Department of Biomedical Sciences and BioMedical Sciences Graduate
    Program (BMSGP)
- name: Shyam Vasvani
  role: author
- name: Sree Samanvitha Kuppa
  role: author
- name: Adityanarayan Mohapatra
  role: author
- name: Amal Babu
  role: author
- name: Yong-Yeon Jeong
  role: author
- name: Hong Yeol Yang
  role: author
- name: Jong Keun Seon
  role: author
- name: Chang-Moon Lee
  role: author
- name: In-Kyu Park
  role: author

## Contact agent



## Publisher

organization: Taylor & Francis

## Managing organization



## Keyword

- subject: Gout inflammation
  schema: not_defined
- subject: reactive oxygen species-responsive release
  schema: not_defined
- subject: hyaluronic acid micelle
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Science and Technology of Advanced Materials
  issn: '14686996'
  volume: '26'
  article_number: '2491304'

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: d669f9a5-e544-47bc-99e9-c9a142c1cd1a
  filename: Macrophage targeting precision nanomedicine utilizing ROS-responsive metallozyme-loaded
    nanomicelle for enhanced treatment of gout-induced inflammatio.pdf
  content_type: application/pdf
  size: 7545950
  md5: 4d00aa1cece8109068809df611b5fcbf

## Thumbnail

fileset_id: d669f9a5-e544-47bc-99e9-c9a142c1cd1a
filename: Macrophage targeting precision nanomedicine utilizing ROS-responsive metallozyme-loaded
  nanomicelle for enhanced treatment of gout-induced inflammatio.pdf