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The excessive accumulation of monosodium urate crystals in joints leads to the pathological condition known as gout. While conventional treatments, which include Non-steroidal Anti-inflammatory Drugs, are available, their short half-life and low bioavailability limit their practical application. To overcome these limitations and leverage the Reactive Oxygen Species (ROS)-rich microenvironment, this study developed a novel ROS-responsive thioketal-linked hyaluronic acid-based micelle loaded with manganese oxide (HTO-MnO) for enhanced treatment. Following the synthesis of the HTO-MnO nanocomplex, the micelle was well characterized and the synthesized micelle were subjected to multiple tests to confirm their efficacy in reducing ROS. In addition, the in-vitro treatment of M1-polarized macrophages showed significant responses at both the gene and protein expression levels. Eventually, in-vivo analysis of the HTO-MnO nanoparticles was performed in the MSU-induced arthritis mouse model. The elevated ROS levels in the ankle joint of the mice triggered the release of MnO nanoparticles from the HTO micelles, suppressing the ROS levels and repolarizing macrophages to their M0 state, thereby effectively mitigating inflammation. This study demonstrates the potential of nanocomplex to reduce ankle swelling and intrinsic ROS levels by targeting M1 macrophages. The results highlight its precise therapeutic mechanism to alleviate inflammation and treat gouty arthritis.

権利情報:

• Creative Commons BY-NC Attribution-NonCommercial 4.0 International
  

キーワード: Gout inflammation, reactive oxygen species-responsive release, hyaluronic acid micelle

刊行年月日: 2025-12-31

出版者: Taylor & Francis

掲載誌:

• Science and Technology of Advanced Materials (ISSN: 14686996) vol. 26 2491304

研究助成金:

原稿種別: 著者最終稿 (Accepted manuscript)

MDR DOI: https://doi.org/10.48505/nims.5452

公開URL: https://doi.org/10.1080/14686996.2025.2491304

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更新時刻: 2025-07-16 16:14:51 +0900

MDRでの公開時刻: 2025-04-24 16:22:39 +0900