# Solvent-Driven Biphasic Architectures in Polymer Gels via Polymerization-Induced Solvent Phase Separation

https://mdr.nims.go.jp/datasets/21d1933b-1274-4cdd-8caf-7ddc38d9f107

## File

- [jacs.6c03722.pdf](https://mdr.nims.go.jp/filesets/f15ad116-21b0-4ba5-bffa-875396b82935/download) ([Detail](https://mdr.nims.go.jp/filesets/f15ad116-21b0-4ba5-bffa-875396b82935.md))

## Id

21d1933b-1274-4cdd-8caf-7ddc38d9f107

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-08-20T05:51:09.673396Z

## Updated at

2026-08-24T01:05:43.274558Z

## Published at

2026-08-24T03:27:03.441158Z

## Doi



## First published url

https://doi.org/10.1021/jacs.6c03722

## Date published

2026-07-01

## Recorded date published



## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Solvent-Driven Biphasic Architectures in Polymer Gels via Polymerization-Induced
    Solvent Phase Separation
  title_type: original
  lang: en

## Description

- description: Polymer gels with biphasic architectures enable diverse functions,
    such as enhanced mechanical robustness and programmable drug release. Conventional
    fabrication of biphasic gels typically relies on the copolymerization of monomers
    with differing solvent affinities, which constrains structural diversity and tunability.
    In this study, we introduce “polymerization-induced solvent phase separation”
    (PI-SPS) as a novel and facile solvent-driven strategy for constructing biphasic
    gels. Polymerization of a homogeneous precursor solution containing two mutually
    immiscible solvents and a monomer triggers solvent demixing, yielding a hierarchical
    structure in which a polymer-rich continuous phase composed of the good solvent
    encapsulates dispersed droplets of the less favorable solvent-rich phase. We demonstrate
    the generality of PI-SPS across systems comprising water, organic solvents, and
    ionic liquids. The resulting biphasic architectures confer emergent properties,
    including self-healing ability, shape-memory behavior, and enhanced crack resistance,
    with a fracture energy of 4600 J m–2 derived from the spatial organization of
    solvent domains and polymer networks. Overall, the PI-SPS strategy provides a
    versatile platform for engineering multiphase soft materials through controlled
    tuning of solvent affinities.
  description_type: abstract
  lang: eng

## Creator

- name: Yuji Kamiyama
  role: author
  orcid: https://orcid.org/0000-0001-9483-2112
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Macromolecules Field/Molecular
    Design and Function Group
- name: Ryota Tamate
  role: author
  orcid: https://orcid.org/0000-0002-1704-1058
  organization: National Institute for Materials Science
  department: Research Center for Macromolecules and Biomaterials/Macromolecules Field/Molecular
    Design and Function Group

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

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## Keyword

- subject: Gels
  schema: not_defined
- subject: Biphasic
  schema: not_defined
- subject: Ionic liquids
  schema: not_defined
- subject: Ion gels
  schema: not_defined
- subject: Solvent phase separation
  schema: not_defined
- subject: Self-healing
  schema: not_defined
- subject: Shape-memory
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Journal of the American Chemical Society
  issn: '00027863'
  volume: '39'
  issue: '8'

## Conference



## Related item



## Funding

- identifier: 23K26409
  funder_name: Japan Society for the Promotion of Science
- identifier: 26K01248
  funder_name: Japan Society for the Promotion of Science

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## Fileset

- id: f15ad116-21b0-4ba5-bffa-875396b82935
  filename: jacs.6c03722.pdf
  content_type: application/pdf
  size: 9604946
  md5: 22fa4e84f18096d3159cca4c6b7ce990

## Thumbnail

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filename: jacs.6c03722.pdf