# NO tablet: autonomous generation of therapeutic nitric oxide in air through redox-promoted CO            <sub>2</sub>            adsorption

https://mdr.nims.go.jp/datasets/20278489-4936-43a4-b43a-fb0fa48313a7

## File

- [NO tablet  autonomous generation of therapeutic nitric oxide in air through redox-promoted CO2 adsorption.pdf](https://mdr.nims.go.jp/filesets/df38b198-a2fc-48f4-9d93-62a8b438e11d/download) ([Detail](https://mdr.nims.go.jp/filesets/df38b198-a2fc-48f4-9d93-62a8b438e11d.md))

## Id

20278489-4936-43a4-b43a-fb0fa48313a7

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-04-11T12:47:46.543750Z

## Updated at

2025-04-14T07:31:09.941042Z

## Published at

2025-04-14T05:56:19.757857Z

## Doi



## First published url

https://doi.org/10.1080/14686996.2025.2474788

## Date published

2025-12-31

## Recorded date published

2025-12-31

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: 'NO tablet: autonomous generation of therapeutic nitric oxide in air through
    redox-promoted CO            <sub>2</sub>            adsorption'
  title_type: original
  lang: en

## Description

- description: Inhaled nitric oxide (iNO) is a powerful therapy for the treatment
    of various cardiopulmonary and respiratory diseases. However, access to iNO therapy
    is often limited by the necessity of cumbersome gas tanks and/or elaborate gas
    blending apparatus. Here, we report a lightweight, inexpensive, and maintenance-free
    tablet that autonomously generates a therapeutic quantity of NO in air. The tablet
    is composed of a thimble filter paper containing a powdery mixture of nitrite
    (NO2‒)-type layered double hydroxide (NLDH) and ascorbic acid loaded on silica
    gel (AASiO2). NLDH by itself generates trace amounts of NO in the air due to the
    left-shifting of the protonation equilibrium of NO2‒ by aerial CO2 and H2O (2[NO2‒]LDH
    + CO2 + H2O ⇌ 2HNO2↑ + [CO32‒]LDH), which is followed by disproportionation of
    2HNO2 to NO, NO2 and H2O. In contrast, it was found that the protonation equilibrium
    can be shifted to the right side when volatile acid products (HNO2 and NO2) are
    readily converted to neutral NO over the AASiO2 reductant. Based on this, even
    a single tablet (containing 0.30 g NLDH and 0.90 g AASiO2) generates 5~20 ppm
    NO at 0.5 L/min for 24 h, which is sufficient to be useful for the relief of severe
    hypoxia caused by persistent pulmonary hypertension of the newborn (PPHN). Moreover,
    the tablet can be activated by exhaled breath for high-dose iNO therapy (80~180
    ppm for several hours), revealing its potential utility for treating viral pneumonia.
    The NO tablet can be stored stably over long periods at ambient temperature in
    a gas barrier bag, and has the potential to break the logistical, financial, and
    operational barriers that have long existed to the widespread implementation of
    iNO therapy.
  description_type: abstract
  lang: und

## Creator

- name: Shinsuke Ishihara
  role: author
  orcid: https://orcid.org/0000-0001-6854-6032
- name: Jan Labuta
  role: author
  orcid: https://orcid.org/0000-0002-8329-0634
- name: Jonathan P. Hill
  role: author
  orcid: https://orcid.org/0000-0002-4229-5842
- name: Takashi Nakanishi
  role: author
  orcid: https://orcid.org/0000-0002-8744-782X
- name: Manabu Kakinohana
  role: author
- name: Nobuo Iyi
  role: author
  orcid: https://orcid.org/0000-0001-5547-7031

## Contact agent



## Publisher

organization: Informa UK Limited

## Managing organization



## Keyword

- subject: Nitric oxide
  schema: not_defined
- subject: medical device
  schema: not_defined
- subject: critical care
  schema: not_defined
- subject: layered double hydroxide
  schema: not_defined
- subject: CO2 adsorption
  schema: not_defined
- subject: equilibrium shift
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Science and Technology of Advanced Materials
  issn: '14686996'
  volume: '26'
  issue: '1'

## Conference



## Related item



## Funding

- funder_name: the JSPS KAKENHI

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: df38b198-a2fc-48f4-9d93-62a8b438e11d
  filename: NO tablet  autonomous generation of therapeutic nitric oxide in air through
    redox-promoted CO2 adsorption.pdf
  content_type: application/pdf
  size: 5952507
  md5: 22df0fc589ad291d930fc2410719b346

## Thumbnail

fileset_id: df38b198-a2fc-48f4-9d93-62a8b438e11d
filename: NO tablet  autonomous generation of therapeutic nitric oxide in air through
  redox-promoted CO2 adsorption.pdf