# Bisphenol A-responsive microgel comprising hydrophilic poly(acrylamide) network

https://mdr.nims.go.jp/datasets/1f9fd49a-cf00-40e6-82a0-539a9f656631

## Files

- [Bisphenol A-responsive microgel comprising hydrophilic poly acrylamide  network.pdf](https://mdr.nims.go.jp/filesets/68b272af-1f47-432f-a620-a54394bbfab7/download) ([Detail](https://mdr.nims.go.jp/filesets/68b272af-1f47-432f-a620-a54394bbfab7.md))
- [BPA-responsiveMicrogel(SI)-R1(Submit).pdf](https://mdr.nims.go.jp/filesets/c642b2c9-5f82-4d77-9d04-07545832133c/download) ([Detail](https://mdr.nims.go.jp/filesets/c642b2c9-5f82-4d77-9d04-07545832133c.md))
- [STAM-2025-0510_data.zip](https://mdr.nims.go.jp/filesets/f37b4a59-bda3-4ff1-9e72-a7862d3f9207/download) ([Detail](https://mdr.nims.go.jp/filesets/f37b4a59-bda3-4ff1-9e72-a7862d3f9207.md))

## Id

1f9fd49a-cf00-40e6-82a0-539a9f656631

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2026-01-16T05:11:31.143077Z

## Updated at

2026-02-03T06:04:59.406468Z

## Published at

2026-01-19T03:21:37.833817Z

## Doi

https://doi.org/10.48505/nims.6137

## First published url

https://doi.org/10.1080/14686996.2025.2610881

## Date published

2026-12-31

## Recorded date published

2026-12-31

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Bisphenol A-responsive microgel comprising hydrophilic poly(acrylamide) network
  title_type: original
  lang: en

## Description

- description: Stimuli-responsive microgels that exhibit rapid changes in size in
    response to external stimuli such as pH and temperature are of great interest
    for the development of smart sensors, drug delivery carriers, and separation materials.
    This paper describes the preparation of molecule-responsive microgels with molecular
    recognition sites comprising a hydrophilic network via inverse miniemulsion polymerization
    using a water-soluble emulsifier. The water-soluble emulsifier comprising hydrophilic
    poly(sulfobetaine) and hydrophilic/oleophilic poly[oligo(ethylene glycol)methacrylate-co-2-(2’-methoxyethoxy)ethyl
    methacrylate] blocks were synthesized via reversible addition fragmentation chain
    transfer (RAFT) polymerization. The resulting block copolymer, PSB-POEG, stabilized
    the water-chloroform interface in a water-in-oil (W/O) emulsion. Water droplets
    in a W/O emulsion stabilized with PSB-POEG allowed the inverse miniemulsion polymerization
    of acrylamide (AAm), acryloyl-modified β-cyclodextrin (CD), and N,N’-methylenebisacrylamide
    to obtain CD-conjugated PAAm microgels with a diameter of approximately 150 nm.
    The resulting CD-PAAm microgels were stably dispersed in an aqueous medium by
    the addition of water, followed by evaporation of chloroform. The CD-PAAm microgels
    exhibited rapid shrinkage in response to bisphenol A (BPA) owing to the formation
    of CD-BPA-CD complexes acting as dynamic cross-links. The proposed method for
    preparing hydrophilic microgels by inverse miniemulsion polymerization using a
    water-soluble emulsifier allows the preparation of molecularly imprinted and bioconjugated
    microgels, providing a useful platform for designing rapidly responsive soft nanomaterials
    for molecular sensors, separation substrates, and drug delivery carriers.
  description_type: abstract
  lang: en

## Creator

- name: Akifumi Kawamura
  role: author
  organization: Kansai University
  department: a Department of Chemistry and Materials Engineering
- name: Fumiya Tanaka
  role: author
- name: Yuriko Nishimura
  role: author
- name: Takashi Miyata
  role: author

## Contact agent



## Publisher

organization: Taylor & Francis

## Managing organization



## Keyword

- subject: Molecule-responsive microgel
  schema: not_defined
- subject: inverse miniemulsion polymerization
  schema: not_defined
- subject: Water-soluble emulsifier
  schema: not_defined
- subject: RAFT polymerization
  schema: not_defined
- subject: zwitterionic polymer
  schema: not_defined
- subject: inclusion complex
  schema: not_defined
- subject: Cyclodextrin
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Science and Technology of Advanced Materials
  issn: '14686996'
  volume: '27'
  article_number: '2610881 '

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 68b272af-1f47-432f-a620-a54394bbfab7
  filename: Bisphenol A-responsive microgel comprising hydrophilic poly acrylamide  network.pdf
  content_type: application/pdf
  size: 2405269
  md5: dab353e13a3cc6a02f2a3c0830584a8f
- id: c642b2c9-5f82-4d77-9d04-07545832133c
  filename: BPA-responsiveMicrogel(SI)-R1(Submit).pdf
  content_type: application/pdf
  size: 488162
  md5: 1bca73e38044b907436e71da84a22d21
- id: f37b4a59-bda3-4ff1-9e72-a7862d3f9207
  filename: STAM-2025-0510_data.zip
  content_type: application/zip
  size: 10052741
  md5: 005f8b398b96988b03fc060a0845d4a9

## Thumbnail

fileset_id: 68b272af-1f47-432f-a620-a54394bbfab7
filename: Bisphenol A-responsive microgel comprising hydrophilic poly acrylamide  network.pdf