# Label-free classification of growth-arrested state of cells by quantitative phase microscopy in fixative-treated cells

https://mdr.nims.go.jp/datasets/1b3df185-eee6-4196-9c52-3ae194267180

## File

- [Najmina-STAMmethod25_QPM.pdf](https://mdr.nims.go.jp/filesets/c0108ee5-e1bd-4251-9d55-a1242d2a04e4/download) ([Detail](https://mdr.nims.go.jp/filesets/c0108ee5-e1bd-4251-9d55-a1242d2a04e4.md))

## Id

1b3df185-eee6-4196-9c52-3ae194267180

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-07-25T01:58:45.099307Z

## Updated at

2025-08-04T03:30:27.516970Z

## Published at

2025-08-04T03:17:08.445622Z

## Doi



## First published url

https://doi.org/10.1080/27660400.2025.2525061

## Date published

2025-12-31

## Recorded date published

2025-12-31

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Label-free classification of growth-arrested state of cells by quantitative
    phase microscopy in fixative-treated cells
  title_type: original
  lang: en

## Description

- description: In the current work, we take advantage of protein accumulation to distinguish
    senescence cells from other cells. The protein concentration is visualized by
    recording the phase difference using the quantitative phase microscopy (QPM).
    Our live QPM observations on breast cancer cells confirms that senescent cells
    exhibit a higher refractive index compared to cells in normal growth and quiescent
    states, attributed to the accumulation of undigested lysosomal protein cargo.
  description_type: abstract
  lang: eng

## Creator

- name: Mazaya Najmina
  role: author
  organization: National Institute for Materials Science
- name: Nicholaus Kevin Tanjaya
  role: author
  orcid: https://orcid.org/0000-0003-4126-8540
  organization: National Institute for Materials Science
- name: Satoshi Ishii
  role: author
  orcid: https://orcid.org/0000-0003-0731-8428
  organization: National Institute for Materials Science
- name: Koichiro Uto
  role: author
  orcid: https://orcid.org/0000-0001-7091-0585
  organization: National Institute for Materials Science

## Contact agent



## Publisher

organization: Informa UK Limited

## Managing organization



## Keyword

- subject: Label-free classification
  schema: not_defined
- subject: Growth-arrested state
  schema: not_defined
- subject: Quantitative phase microscopy
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: 'Science and Technology of Advanced Materials: Methods'
  issn: '27660400'
  volume: '5'
  issue: '1'
  article_number: '2525061'

## Conference



## Related item



## Funding

- identifier: JPMJFR2327
  funder_name: JST FOREST Program
- identifier: JP20H05877
  funder_name: Grant-in-Aid for Transformative Research Areas
- funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Custom property



## Fileset

- id: c0108ee5-e1bd-4251-9d55-a1242d2a04e4
  filename: Najmina-STAMmethod25_QPM.pdf
  content_type: application/pdf
  size: 7848089
  md5: 4727cbae123b484578151d54788acab6

## Thumbnail

fileset_id: c0108ee5-e1bd-4251-9d55-a1242d2a04e4
filename: Najmina-STAMmethod25_QPM.pdf