# Inosine pranobex-derived coordination complexes for self-adjuvant, self-carrier, and self-assembled vaccines in cancer immunotherapy

https://mdr.nims.go.jp/datasets/1a0e611e-15b1-4513-8d69-7deb34be107b

## File

- [APMT -著者最終稿.pdf](https://mdr.nims.go.jp/filesets/45a3a183-98cb-4f00-bb16-958101755a80/download) ([Detail](https://mdr.nims.go.jp/filesets/45a3a183-98cb-4f00-bb16-958101755a80.md))

## Id

1a0e611e-15b1-4513-8d69-7deb34be107b

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-09-18T07:30:35.598725Z

## Updated at

2024-09-19T02:56:10.836566Z

## Published at

2026-06-25T23:27:44.459160Z

## Doi

https://doi.org/10.48505/nims.4760

## First published url

https://doi.org/10.1016/j.apmt.2024.102299

## Date published

2024-06-26

## Recorded date published

2024-8

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Inosine pranobex-derived coordination complexes for self-adjuvant, self-carrier,
    and self-assembled vaccines in cancer immunotherapy
  title_type: original
  lang: en

## Description

- description: Inosine pranobex (InP), an immunomodulatory drug approved for clinical
    use worldwide, is a potential adjuvant for cancer vaccines with a low clinical
    translation barrier. However, the administration of soluble InP agents in free
    format is associated with drawbacks of a short half-life period and limited efficacy.
    In this study, a rapid self-assembly approach was proposed for the synthesis of
    cancer vaccines due to the coordination interaction of ferric ion and acedoben
    (Ace) in InP. The self-assembled cancer vaccines can be readily adjusted from
    the microscale to the nanoscale, with shapes including rods, fibers, and spheres.
    Herein, Fe-Ace coordination complexes not only serve as carriers for tumor antigens,
    but also enhance antigen-specific antitumor immunity due to their intrinsic adjuvant
    properties. Nanofibrous self-assembled cancer vaccines based on Fe-Ace coordination
    complexes more effectively induced an antitumor immune response, exerted a remarkable
    therapeutic effect, and inhibited the tumor growth at distant site in vivo, compared
    to free InP and other self-assembled cancer vaccines. The presented work provides
    a promising strategy for the rapid manufacture of InP-derived self-adjuvant, self-carrier,
    and self-assembled vaccines for cancer immunotherapy.
  description_type: abstract
  lang: en

## Creator

- name: Xia Li
  role: author
  orcid: https://orcid.org/0000-0002-3246-4462
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Shinya Hattori
  role: author
  orcid: https://orcid.org/0000-0002-2635-2464
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Tomohiko Yamazaki
  role: author
  orcid: https://orcid.org/0000-0003-2136-8042
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Naoto Shirahata
  role: author
  orcid: https://orcid.org/0000-0002-1217-7589
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Nobutaka Hanagata
  role: author
  orcid: https://orcid.org/0000-0001-6079-3426
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26

## Contact agent



## Publisher

organization: Elsevier BV

## Managing organization



## Keyword

- subject: cancer immunotherapy
  schema: not_defined
- subject: therapeutic cancer vaccines
  schema: not_defined
- subject: coordination complexes
  schema: not_defined
- subject: inosine pranobex
  schema: not_defined
- subject: self-assembly
  schema: not_defined

## Rights

- description: "© 2024. This manuscript version is made available under the CC-BY-NC-ND
    4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/"
  identifier: https://creativecommons.org/licenses/by-nc-nd/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2024-06-26
end_date: 2026-06-26

## Journal

- title: Applied Materials Today
  issn: '23529407'
  volume: '39'
  article_number: '102299'

## Conference



## Related item



## Funding

- identifier: JPMXP1223NM5201
  funder_name: Ministry of Education, Culture, Sports, Science and Technology
- funder_name: Takeda Science Foundation
- funder_name: National Institute for Materials Science
- identifier: 22K20517
  funder_name: Japan Society for the Promotion of Science
- identifier: 23K04555
  funder_name: Japan Society for the Promotion of Science

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## Fileset

- id: 45a3a183-98cb-4f00-bb16-958101755a80
  filename: APMT -著者最終稿.pdf
  content_type: application/pdf
  size: 4274991
  md5: faa8222d640a7d6aeef3cc2a0eace10b

## Thumbnail

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filename: APMT -著者最終稿.pdf