# Magnetic Induction Heating Enables On-Demand Drug Release via Diels–Alder Polymeric Nanocarriers

https://mdr.nims.go.jp/datasets/153c0595-eb66-4dba-84f2-9de63b066429

## File

- [25_Biomacromolecules.pdf](https://mdr.nims.go.jp/filesets/011b9c59-bbf4-439a-a5c2-c77f3a153602/download) ([Detail](https://mdr.nims.go.jp/filesets/011b9c59-bbf4-439a-a5c2-c77f3a153602.md))

## Id

153c0595-eb66-4dba-84f2-9de63b066429

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-12-16T00:26:00.853082Z

## Updated at

2025-12-18T23:30:20.138494Z

## Published at

2025-12-18T10:08:21.936995Z

## Doi



## First published url

https://doi.org/10.1021/acs.biomac.5c00321

## Date published

2025-11-10

## Recorded date published

2025-11-10

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Magnetic Induction Heating Enables On-Demand Drug Release via Diels–Alder
    Polymeric Nanocarriers
  title_type: original
  lang: en

## Description

- description: As a stimulus-responsive drug release system, we developed Diels–Alder
    (DA) induction-activated magnetic nanoparticles (DiMaN). Functionalization of
    polymer-coated magnetic nanoparticles (mNPs) with drugs via thermoreversible DA
    coupling enabled release through retro-Diels–Alder (rDA) cleavage upon heating.
    The (pDMAm-co-pFMA)-b-pAAc polymer supported mNP formation and drug binding. DA
    coupling with maleimide-functionalized drugs was verified by 1H NMR, showing distinct
    exo (3.23 ppm) and endo (3.48 ppm) signals after 72 h at 37 °C. Approximately
    70% release was observed within 15 min at 80 °C, while the complex maintained
    stability at 40 °C. The superparamagnetic mNPs generated localized heating under
    an alternating current magnetic field (192 kHz, 480 A), raising the solution temperature
    by 6 °C within 5 min. The biotin-maleimide complex demonstrated higher release
    by rDA from furan-containing mNPs (approximately 150 μM) compared to the control
    group (approximately 103 μM). These results highlight DiMaN as a promising platform
    for magnetic-controlled, on-demand drug release.
  description_type: abstract
  lang: und

## Creator

- name: Nanami Fujisawa
  role: author
  orcid: https://orcid.org/0000-0002-8894-1790
  organization: National Institute for Materials Science
- name: Mitsuhiro Ebara
  role: author
  orcid: https://orcid.org/0000-0002-7906-0350
  organization: National Institute for Materials Science
- name: James J. Lai
  role: author

## Contact agent



## Publisher

organization: American Chemical Society (ACS)

## Managing organization



## Keyword

- subject: Diels-Alder reaction
  schema: not_defined
- subject: magnetic hyperthermia
  schema: not_defined
- subject: on-demand
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/
  date_licensed: 2025-10-23

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Biomacromolecules
  issn: '15257797'
  volume: '26'
  issue: '11'
  start_page: 7265
  end_page: 7274

## Conference



## Related item



## Funding

- identifier: JPMXP1224NM5127
  funder_name: Ministry of Education, Culture, Sports, Science and Technology
- identifier: AI163282
  funder_name: National Institute of Allergy and Infectious Diseases
- identifier: 20H05877
  funder_name: Japan Society for the Promotion of Science
- identifier: 22KJ0434
  funder_name: Japan Society for the Promotion of Science

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



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## Fileset

- id: 011b9c59-bbf4-439a-a5c2-c77f3a153602
  filename: 25_Biomacromolecules.pdf
  content_type: application/pdf
  size: 4787493
  md5: 521523a3c1fb298a396c87556528322e

## Thumbnail

fileset_id: 011b9c59-bbf4-439a-a5c2-c77f3a153602
filename: 25_Biomacromolecules.pdf