# Collagen Signaling via DDR1 Exacerbates Barriers to Macromolecular Drug Delivery in a 3D Model of Pancreatic Cancer Fibrosis

https://mdr.nims.go.jp/datasets/1450711b-6f0e-4f83-880b-f72d503c0f0f

## File

- [Small - 2025 - Ohira - Collagen Signaling via DDR1 Exacerbates Barriers to Macromolecular Drug Delivery in a 3D Model of.pdf](https://mdr.nims.go.jp/filesets/12f027df-d57a-4dc6-bf18-a6a533df9b7b/download) ([Detail](https://mdr.nims.go.jp/filesets/12f027df-d57a-4dc6-bf18-a6a533df9b7b.md))

## Id

1450711b-6f0e-4f83-880b-f72d503c0f0f

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-12-05T04:32:40.079700Z

## Updated at

2026-01-06T07:45:26.817735Z

## Published at

2025-12-05T07:24:31.961868Z

## Doi



## First published url

https://doi.org/10.1002/smll.202506926

## Date published

2025-10-31

## Recorded date published

2025-12

## Resource type

journal_article

## Manuscript type

vor

## Collection



## Title

- title: Collagen Signaling via DDR1 Exacerbates Barriers to Macromolecular Drug Delivery
    in a 3D Model of Pancreatic Cancer Fibrosis
  title_type: original
  lang: en

## Description

- description: In this paper, we present that collagen signaling via DDR1 exacerbates
    barriers to macromolecular drug delivery in a 3D model of pancreatic cancer fibrosis.
  description_type: abstract
  lang: eng

## Creator

- name: Mayu Ohira
  role: author
- name: Moe Kitamura
  role: author
- name: Hiroyo Iwasaki
  role: author
- name: Haruko Ohta‐Okano
  role: author
- name: Hiyori Tsujii
  role: author
- name: Reika Nakamura
  role: author
- name: Takuya Nakazawa
  role: author
- name: Akihiro Nishiguchi
  role: author
  orcid: https://orcid.org/0000-0002-3160-6385
  organization: National Institute for Materials Science
- name: Masaya Yamamoto
  role: author
- name: Kensuke Osada
  role: author
- name: Shinichi Toyooka
  role: author
- name: Horacio Cabral
  role: author
- name: Atsushi Masamune
  role: author
- name: Mitsunobu R. Kano
  role: author
- name: Hiroyoshi Y. Tanaka
  role: author

## Contact agent



## Publisher

organization: Wiley

## Managing organization



## Keyword

- subject: 3D model
  schema: not_defined
- subject: cancer
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by-nc/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Small
  issn: '16136810'
  volume: '21'
  issue: '50'
  article_number: e06926

## Conference



## Related item



## Funding

- identifier: JP24H00787
  funder_name: Japan Society for the Promotion of Science
- identifier: JP21H03832
  funder_name: Japan Society for the Promotion of Science
- identifier: JP21K19014
  funder_name: Japan Society for the Promotion of Science
- identifier: JP23K24312
  funder_name: Japan Society for the Promotion of Science
- identifier: JP23H02653
  funder_name: Japan Society for the Promotion of Science
- identifier: JP26293119
  funder_name: Japan Society for the Promotion of Science
- identifier: JP23K06279
  funder_name: Japan Society for the Promotion of Science
- identifier: JP20K16989
  funder_name: Japan Society for the Promotion of Science
- funder_name: Okayama University
- funder_name: Inamori Foundation
- funder_name: Hokuto Foundation for Bioscience
- funder_name: Japan Foundation for Applied Enzymology
- funder_name: Pancreas Research Foundation of Japan
- funder_name: Ryobi Teien Memory Foundation
- identifier: JPMJPF2202
  funder_name: Japan Science and Technology Agency

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 12f027df-d57a-4dc6-bf18-a6a533df9b7b
  filename: Small - 2025 - Ohira - Collagen Signaling via DDR1 Exacerbates Barriers
    to Macromolecular Drug Delivery in a 3D Model of.pdf
  content_type: application/pdf
  size: 16505296
  md5: 23c6023f2a48b59577cbefe47d02664c

## Thumbnail

fileset_id: 12f027df-d57a-4dc6-bf18-a6a533df9b7b
filename: Small - 2025 - Ohira - Collagen Signaling via DDR1 Exacerbates Barriers
  to Macromolecular Drug Delivery in a 3D Model of.pdf