# Effect of sprayable, highly adhesive hydrophobized gelatin microparticles on esophageal stenosis after endoscopic submucosal dissection: an experimental study in a swine model

https://mdr.nims.go.jp/datasets/131f2562-aa04-483f-8122-99a507f8f85e

## File

- [MDR Effect of sprayable....pdf](https://mdr.nims.go.jp/filesets/1591685b-4ac5-48a4-ad65-1951ec9f897e/download) ([Detail](https://mdr.nims.go.jp/filesets/1591685b-4ac5-48a4-ad65-1951ec9f897e.md))

## Id

131f2562-aa04-483f-8122-99a507f8f85e

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2025-04-14T05:19:29.243709Z

## Updated at

2025-04-16T07:30:07.080804Z

## Published at

2025-04-16T05:29:28.345528Z

## Doi

https://doi.org/10.48505/nims.5425

## First published url

https://doi.org/10.1007/s10388-024-01090-8

## Date published

2024-10-15

## Recorded date published

2025-1

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: 'Effect of sprayable, highly adhesive hydrophobized gelatin microparticles
    on esophageal stenosis after endoscopic submucosal dissection: an experimental
    study in a swine model'
  title_type: original
  lang: en

## Description

- description: Esophageal mucosal resection for superficial esophageal cancer can
    lead to postoperative esophageal stricture, with current preventive measures being
    insufficient. Sprayable wound dressings containing hydrophobized microparticles
    exhibit strong adhesion. This study aimed to investigate the preventive effects
    of hydrophobized microparticles on esophageal stenosis following endoscopic submucosal
    dissection. Spraying of hydrophobized microparticles was easily performed using
    an existing endoscopic spraying device. The esophageal stricture rate was significantly
    lower in the sprayed group than in the non-sprayed group (76.1% versus 90.6%,
    p<0.05). The sprayed group showed suppression of inflammatory cell infiltration
    in the submucosal layer (p<0.01) and thickening of the muscular layer (p<0.01).
  description_type: abstract
  lang: und

## Creator

- name: Hiroki Yano
  role: author
- name: Fumisato Sasaki
  role: author
  orcid: https://orcid.org/0000-0003-4824-4154
- name: Hidehito Maeda
  role: author
- name: Shohei Uehara
  role: author
- name: Masayuki Kabayama
  role: author
- name: Yusuke Fujino
  role: author
- name: Akihito Tanaka
  role: author
- name: Makoto Hinokuchi
  role: author
- name: Shiho Arima
  role: author
- name: Shinichi Hashimoto
  role: author
- name: Shuji Kanmura
  role: author
- name: Shima Ito
  role: author
- name: Akihiro Nishiguchi
  role: author
  orcid: https://orcid.org/0000-0002-3160-6385
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530
- name: Akio Ido
  role: author

## Contact agent



## Publisher

organization: Springer Science and Business Media LLC

## Managing organization



## Keyword

- subject: Alaska pollock-derived gelatin; Particle
  schema: not_defined

## Rights

- identifier: https://creativecommons.org/licenses/by/4.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo



## Journal

- title: Esophagus
  issn: '16129059'
  volume: '22'
  issue: '1'
  start_page: 95
  end_page: 104

## Conference



## Related item



## Funding

- identifier: 20 lm0203114h0001
  funder_name: Translational Research Program TR-SPRINT (Strategic PRomotion for practical
    application of INnovative medical Technology) of the Japan Agency of Medical Research
    and Development
- identifier: 19K17467
  funder_name: Japan Society for the Promotion of Science KAKENHI
- identifier: 20H0247
  funder_name: Japan Society for the Promotion of Science KAKENHI
- funder_name: Kagoshima University

## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: 1591685b-4ac5-48a4-ad65-1951ec9f897e
  filename: MDR Effect of sprayable....pdf
  content_type: application/pdf
  size: 755952
  md5: e3a678248fb2c6c2644193a1b4d83565

## Thumbnail

fileset_id: 1591685b-4ac5-48a4-ad65-1951ec9f897e
filename: MDR Effect of sprayable....pdf