# Alaska Pollock-derived Gelatin Sealant has Higher Sealing Strength than, and Comparable Biocompatibility with, Fibrin Sealant in Porcine and Rat Dural Injury Models

https://mdr.nims.go.jp/datasets/10b2f041-7ebd-470d-afa3-800a370f9c5f

## File

- [SPINE 167175_R1-3.pdf](https://mdr.nims.go.jp/filesets/da6b3c78-64f3-4cae-b52a-ec53beaa727d/download) ([Detail](https://mdr.nims.go.jp/filesets/da6b3c78-64f3-4cae-b52a-ec53beaa727d.md))

## Id

10b2f041-7ebd-470d-afa3-800a370f9c5f

## Local identifier



## Visibility

open_to_public

## State

published

## Created at

2024-07-04T01:08:28.186972Z

## Updated at

2025-07-01T03:30:33.030878Z

## Published at

2025-06-30T23:18:03.448700Z

## Doi

https://doi.org/10.48505/nims.4576

## First published url

https://doi.org/10.1097/brs.0000000000004985

## Date published

2024-07-01

## Recorded date published

2024

## Resource type

journal_article

## Manuscript type

accepted_manuscript

## Collection



## Title

- title: Alaska Pollock-derived Gelatin Sealant has Higher Sealing Strength than,
    and Comparable Biocompatibility with, Fibrin Sealant in Porcine and Rat Dural
    Injury Models
  title_type: original
  lang: en

## Description

- description: 'Disruption of the dura mater occurs in neurosurgery and leads to the
    cerebrospinal fluid (CSF) leakage. A fibrin sealant is most frequently applied
    to the ruptured site, but the problem is its lack of sealing strength. A novel
    biocompatible sealant composed of Alaska pollock-derived gelatin (ApGltn) has
    recently shown good burst strength and biocompatibility in a porcine aorta. The
    purpose of this study was to investigate the sealing strength and biocompatibility
    of the ApGltn sealant and fibrin sealant in a porcine and a rat disrupted dura
    injury model. The maximum burst strength of the ApGltn sealant was approximately
    5.7 times higher than that of a fibrin sealant (82.4 ± 13.7 vs. 14.4 ± 9.6 mmHg,
    respectively; p < 0.001). Histological examination confirmed that the ApGltn sealant
    showed tight adhesion to the dura surface, while a gap was observed between the
    fibrin sealant and dura mater. Functional evaluation and histological examination
    in a rat model showed that dura maters repaired with ApGltn sealant showed similar
    recovery compared to repair with the fibrin sealant. '
  description_type: abstract
  lang: und

## Creator

- name: Takumi Ono
  role: author
- name: Taku Suzuki
  role: author
- name: Narihito Nagoshi
  role: author
- name: Yohei Masugi
  role: author
- name: Kosuke Maeda
  role: author
- name: Shogo Hashimoto
  role: author
- name: Shiharu Watanabe
  role: author
- name: Takuji Iwamoto
  role: author
- name: Tetsushi Taguchi
  role: author
  orcid: https://orcid.org/0000-0003-2541-2530
  organization: National Institute for Materials Science
  ror: https://ror.org/026v1ze26
- name: Masaya Nakamura
  role: author

## Contact agent



## Publisher

organization: Ovid Technologies (Wolters Kluwer Health)

## Managing organization



## Keyword

- subject: Alaska pollock-derived gelatin
  schema: not_defined
- subject: Alaska pollock-derived gelatin sealant
  schema: not_defined
- subject: burst strength
  schema: not_defined
- subject: cerebrospinal fluid
  schema: not_defined
- subject: cerebrospinal fluid leakage
  schema: not_defined
- subject: dura
  schema: not_defined
- subject: dural injury
  schema: not_defined

## Rights

- description: 'This is a pre-copyedited, author-produced version of an article accepted
    for publication in Spine. The published version of record Spine 49(13):p E200-E207,
    July 1, 2024. is available online at: https://doi.org/10.1097/BRS.0000000000004985.'
  identifier: http://rightsstatements.org/vocab/InC/1.0/

## Other identifier(s)



## Data origin

- data_origin_type: other

## Embargo

start_date: 2024-07-01
end_date: 2025-07-01

## Journal

- title: Spine
  issn: '03622436'
  volume: '49'
  issue: '13'
  start_page: 0
  end_page: 0

## Conference



## Related item



## Funding



## Instrument



## Instrument operator



## Instrument managing organization



## Measurement method



## Specimen



## Chemical composition



## Structure for specimen



## Structural feature for specimen



## Specific property for specimen



## Process for specimen treatment



## Computational method



## Energy level/transition state



## Software



## Custom property



## Fileset

- id: da6b3c78-64f3-4cae-b52a-ec53beaa727d
  filename: SPINE 167175_R1-3.pdf
  content_type: application/pdf
  size: 966127
  md5: 65bff7e1bd4f62988048e9398830e378

## Thumbnail

fileset_id: da6b3c78-64f3-4cae-b52a-ec53beaa727d
filename: SPINE 167175_R1-3.pdf